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MelmarT Melanoma Margins Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma
NCT02385214 · View on ClinicalTrials.gov ↗
Study Summary
Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with a primary invasive cutaneous melanomas \>=1mm thick to determine differences in the rate of local recurrence and melanoma specific survival. A reduction in margins is expected to improve quality of life in patients
Conditions Studied
Interventions
- PROCEDURE Wide Local Excision = 1cm Margin
- PROCEDURE Wide Local Excision = 2cm Margin
Study Locations (20)
Other
- Sunnybrook Health Sciences Centre — Toronto
- Sahlgrenska University Hospital — Gothenburg
- North Bristol NHS Trust — Bristol
- Cambridge University Hospitals NHS Foundation Trust — Cambridge
- Royal Devon and Exeter NHS Foundation Trust — Exeter
- St. James University Hospital — Leeds
- Royal Free London NHS Foundation Trust — London
- Imperial College Healthcare NHS Trust — London
- Norfolk and Norwich University Hospital — Norwich
England
- Hull and East Yorkshire Hospitals NHS Trust — Hull
- Guy's and St Thomas' Hospital NHS Trust — London
- The Christie NHS Foundation Trust — Manchester
Victoria
- Peter MacCallum Cancer Centre Division of Cancer Surgery — Melbourne
- Alfred Hospital — Melbourne
Pennsylvania
- Thomas Jefferson University Hospital — Philadelphia
New South Wales
- Melanoma Institute Australia - Poche Centre — North Sydney
Queensland
- Gold Coast Melanom Clinic — Coolangatta
Essex
- Mid Essex Hospital Services NHS Trust — Broomfield
Mersyside
- St Helens & Knowsley NHS Trust — St Helens
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2015-01-03 |
| Est. Completion | 2026-08-05 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02385214
The ClinicalTrials.gov registry entry for NCT02385214 describes a study currently listed as active not recruiting. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 400 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Melanoma and Skin Cancer Trials Limited, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Cutaneous Melanoma by AJCC V7 Stage appearing as the primary indexed condition, and to 2 interventions — of which Wide Local Excision = 1cm Margin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02385214 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Other, England, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02385214 about?
NCT02385214 is a clinical study titled "MelmarT Melanoma Margins Trial Investigating 1cm v 2cm Wide Excision Margins for Primary Cutaneous Melanoma". Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for ...
What is the current status of trial NCT02385214?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 400 participants. The study started on 2015-01-03. Estimated completion is 2026-08-05.
What conditions does trial NCT02385214 study?
This clinical trial studies the following conditions: Cutaneous Melanoma by AJCC V7 Stage. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02385214?
The interventions under investigation include: Wide Local Excision = 1cm Margin (PROCEDURE), Wide Local Excision = 2cm Margin (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02385214?
This trial is sponsored by Melanoma and Skin Cancer Trials Limited, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02385214 being conducted?
This trial has 20 study locations across Pennsylvania, New South Wales, Queensland, Victoria, England. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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