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NCT02359006 · ClinicalTrials.gov registry record · NA
The Effects of Minocycline in Opioid-maintained Patients
A NA study, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 27
- Enrollment target
NCT02359006 is a NA study that has completed, run by Yale University. The registered enrollment target is 27 participants.
The verdict
NCT02359006, a NA study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 27 participants
- Enrollment target
Study Summary
Opioids are the most commonly utilized pharmacological treatment for moderate to severe pain. However, their clinical value is hindered by the development of opioid-induced hyperalgesia (OIH). OIH manifests as heightened pain sensitivity, and is an increasingly challenging drawback to the efficacy of opioid treatment. Although the mechanism of action modulating OIH is not completely understood, previous animal studies suggest that this phenomenon is a result of proinflammatory responses. Thus, administering an adjunct anti-inflammatory agent may attenuate OIH. Minocycline is one such agent; it is a tetracycline derivative antibiotic that inhibits microglia activation, nitric oxide (NO) production, and the release of pro-inflammatory cytokines and chemokines. In fact, recent evidence suggests that minocycline may attenuate the neuroinflammatory effects of opioids while enhancing their antinociceptive effects. Therefore, the investigators will determine if minocycline will mitigate OIH in methadone-maintained patients.
Interventions
- DRUG Placebo
- DRUG Minocycline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2015-03-12 |
| Est. Completion | 2017-04-19 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02359006
The ClinicalTrials.gov registry entry for NCT02359006 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 27 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT02359006 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02359006 about?
NCT02359006 is a clinical study titled "The Effects of Minocycline in Opioid-maintained Patients". Opioids are the most commonly utilized pharmacological treatment for moderate to severe pain. However, their clinical value is hindered by the development of opioid-induced hyperalgesia (OIH). OIH manifests as heightened pain sensitivity, and is an increasingly challenging drawback to the efficacy o...
What is the current status of trial NCT02359006?
This trial is currently completed. It is a NA study. The enrollment target is 27 participants. The study started on 2015-03-12. Estimated completion is 2017-04-19.
What interventions are being tested in trial NCT02359006?
The interventions under investigation include: Placebo (DRUG), Minocycline (DRUG).
Who is sponsoring clinical trial NCT02359006?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
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