Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02358499 · ClinicalTrials.gov registry record · Phase 1
Genetic Variation and Variability in Posaconazole Pharmacokinetics in Children
A Phase 1 study of Fungal Infections, sponsored by Children's Mercy Hospital Kansas City.
- Completed
- Registry status
- Phase 1
- Development phase
- 31
- Enrollment target
- 1
- Study location
NCT02358499: Completed Phase 1 study of Fungal Infections, sponsored by Children's Mercy Hospital Kansas City.
NCT02358499 is a Phase 1 study of Fungal Infections that has completed, run by Children's Mercy Hospital Kansas City. The registered enrollment target is 31 participants, below the 320-participant average among 3 other Fungal Infections trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02358499, a Phase 1 study of Fungal Infections, has completed, sponsored by Children's Mercy Hospital Kansas City.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 31 participants
- Enrollment target
- 1
- Study location
Study Summary
The main goal of this study is to see how the body breaks down an antifungal drug named posaconazole in children with certain cancers, blood disorders, or transplantation of bone marrow or similar blood cells. This study will also help us learn whether a child's age, genetics, or disease affect how well the body breaks down posaconazole.
Primary Outcome
Posaconazole concentrations in the plasma will be measured after a single dose of posaconazole injection to estimate the area under the concentration-versus-time curve (AUC). Blood samples for the assessment of AUC will be collected predose on Day 1 and then at specified time points up to 96 hours postdose.
Conditions Studied
Interventions
- DRUG Posaconazole
Study Locations (1)
Missouri
- Children's Mercy Hospital Kansas City - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2015-01 |
| Est. Completion | 2018-12-31 |
| Phase | Phase 1 |
What the finished NCT02358499 record still lists
NCT02358499 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 31 participants, a relatively small participant target, below the 320-participant average among 3 other Fungal Infections trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Fungal Infections appearing as the primary indexed condition, and to 1 intervention - of which Posaconazole is the first listed.
NCT02358499 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT02358499 about?
NCT02358499 is a clinical study titled "Genetic Variation and Variability in Posaconazole Pharmacokinetics in Children". The main goal of this study is to see how the body breaks down an antifungal drug named posaconazole in children with certain cancers, blood disorders, or transplantation of bone marrow or similar blood cells. This study will also help us learn whether a child's age, genetics, or disease affect how ...
What is the current status of trial NCT02358499?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 31 participants. The study started on 2015-01. Estimated completion is 2018-12-31.
What conditions does trial NCT02358499 study?
This clinical trial studies the following conditions: Fungal Infections.
What interventions are being tested in trial NCT02358499?
The interventions under investigation include: Posaconazole (DRUG).
Who is sponsoring clinical trial NCT02358499?
This trial is sponsored by Children's Mercy Hospital Kansas City, which has 184 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02358499 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Fungal Infections
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
A Pilot of Pediatric/Adult Study of Gene Expression Profiling and Clinical Characterization of Phototoxicity
COMPLETED · Phase 1
-
Studies of Disorders With Increased Susceptibility to Fungal Infections
RECRUITING
-
Pharmacokinetic Profile of Inhaled Liposomal Amphotericin B in Lung Transplant Recipients - Ambisome Study
COMPLETED · Phase 3
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02932618 · 31 participants · Phase 3
A Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebrand Disease (VWD)
- NCT03482297 · 31 participants · Phase 1
Automated Abdominal Binder for Orthostatic Hypotension
- NCT04016389 · 31 participants · NA
FIGO 2018 Stage IB2 Cervical Cancer Treated With Neoadjuvant Chemotherapy Followed by Fertility Sparing Surgery
- NCT04211675 · 31 participants · Phase 1
NK Cells Infusions With Irinotecan, Temozolomide, and Dinutuximab
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia