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NCT02237625 · ClinicalTrials.gov registry record
Natural History Study of Patients With Hypophosphatasia (HPP)
A clinical trial of Hypophosphatasia, sponsored by Duke University.
- Recruiting
- Registry status
- 200
- Enrollment target
- 1
- Study location
NCT02237625 is a study of Hypophosphatasia that is actively recruiting participants, run by Duke University. The registered enrollment target is 200 participants, above the 51-participant average among 6 other Hypophosphatasia trials with a reported enrollment target (292% higher). The trial reports 1 study location across 1 state.
The verdict
NCT02237625, a study of Hypophosphatasia, is actively recruiting participants, sponsored by Duke University.
- RECRUITING
- Registry status
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
Hypophosphatasia (HPP) is a rare inherited metabolic disorder characterized by defective bone and teeth mineralization caused by mutations of the ALPL gene, which encodes for the tissue-nonspecific alkaline phosphatase (TNSALP) isozyme, resulting in decreased serum and bone alkaline phosphatase levels. To date, over 250 different mutations in the gene encoding TNSALP have been associated with HPP. Clinically, the loss of TNSALP function results in progressive skeletal impact as well as progressive impact on all other major organ systems. It clinically manifests as rickets in infants and children and osteomalacia at all ages. The severe form of the disease has been estimated to have a prevalence of about 1 in every 100,000 live births.
Conditions Studied
Study Locations (1)
North Carolina
- Duke University Medical Center - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2014-09 |
| Est. Completion | 2028-09 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02237625
The ClinicalTrials.gov registry entry for NCT02237625 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 51-participant average among 6 other Hypophosphatasia trials with a reported enrollment target (292% higher). The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Hypophosphatasia appearing as the primary indexed condition, and to 0 interventions.
NCT02237625 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT02237625 about?
NCT02237625 is a clinical study titled "Natural History Study of Patients With Hypophosphatasia (HPP)". Hypophosphatasia (HPP) is a rare inherited metabolic disorder characterized by defective bone and teeth mineralization caused by mutations of the ALPL gene, which encodes for the tissue-nonspecific alkaline phosphatase (TNSALP) isozyme, resulting in decreased serum and bone alkaline phosphatase leve...
What is the current status of trial NCT02237625?
This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2014-09. Estimated completion is 2028-09.
What conditions does trial NCT02237625 study?
This clinical trial studies the following conditions: Hypophosphatasia.
Who is sponsoring clinical trial NCT02237625?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02237625 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypophosphatasia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
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United States Hypophosphatasia Molecular Research Center
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A Prospective Sub-Study of the Global Hypophosphatasia Registry
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Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa
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-
Phase 3 Study of ALXN1850 in Treatment-Naïve Pediatric Participants With HPP
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-
Phase 3 Study of ALXN1850 Versus Placebo in Adolescent and Adult Participants With HPP Who Have Not Previously Been Treated With Asfotase Alfa
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-
Extension Study of Protocol ENB-002-08 - Study of Asfotase Alfa in Infants and Young Children With Hypophosphatasia (HPP)
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Read our methodology - how this data is sourced, computed, and verified.
Related
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