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NCT02227472 · ClinicalTrials.gov registry record
Working Memory and School Readiness in Preschool-Aged Children With Sickle Cell Disease
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 84
- Enrollment target
NCT02227472: Completed study, sponsored by St. Jude Children's Research Hospital.
NCT02227472 is a clinical trial that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 84 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02227472 has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 84 participants
- Enrollment target
Study Summary
Children with sickle cell disease (SCD) are at risk for neurobehavioral problems because of the impact the disease can have on the central nervous system. Specific impairments in working memory are particularly prevalent in school-aged children with SCD. Working memory is more strongly associated with school readiness and academic success than intellectual ability in the general population. The adverse effects of low socioeconomic status (SES) and poverty on cognition and neurodevelopment emerge early, before children have entered formal education. In addition, they affect language and executive function skills (e.g., working memory) more than other skills. SES is a proxy variable for other risk factors. Higher SES is associated with less parental stress, more supportive parenting practices, and better cognitive stimulation based on the availability of books, computers, and outings. PRIMARY OBJECTIVE: * To examine working memory and school readiness in young children with sickle cell disease in comparison to demographically matched control children without sickle cell disease. SECONDARY OBJECTIVE: * To examine the relationships of family/environmental factors (caregiver stress, parental responsiveness, and cognitive stimulation in the home) and disease severity to working memory and school readiness skills in preschool-aged children with SCD.
Primary Outcome
Variables will be subjected to analyses to establish frequency distributions, means and standard deviations, and to determine if variables are normally distributed prior to use of parametric statistics. The primary dependent variable for working memory ability is the Working Memory Index from the SB-5. Primary dependent variables will be compared statistically using a paired sample one-side t-test.
Interventions
- OTHER Evaluation of cognitive and pre-academic skills
- OTHER Parent questionnaires
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 84 participants |
| Start Date | 2014-09-08 |
| Est. Completion | 2018-08-20 |
What the finished NCT02227472 record still lists
NCT02227472 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 84 participants, a relatively small participant target.
The record links to 0 conditions, and to 2 interventions - of which Evaluation of cognitive and pre-academic skills is the first listed.
NCT02227472 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02227472 about?
NCT02227472 is a clinical study titled "Working Memory and School Readiness in Preschool-Aged Children With Sickle Cell Disease". Children with sickle cell disease (SCD) are at risk for neurobehavioral problems because of the impact the disease can have on the central nervous system. Specific impairments in working memory are particularly prevalent in school-aged children with SCD. Working memory is more strongly associated wi...
What is the current status of trial NCT02227472?
This trial is currently completed. The enrollment target is 84 participants. The study started on 2014-09-08. Estimated completion is 2018-08-20.
What interventions are being tested in trial NCT02227472?
The interventions under investigation include: Evaluation of cognitive and pre-academic skills (OTHER), Parent questionnaires (OTHER).
Who is sponsoring clinical trial NCT02227472?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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