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COMPLETED Phase 1

A Study to Assess Safety and Pharmacokinetics of MOXR0916 in Participants With Locally Advanced or Metastatic Solid Tumors

NCT02219724 · View on ClinicalTrials.gov ↗

Study Summary

This is a first-in-human, Phase 1, open-label, multicenter, dose-escalation study designed to evaluate the safety, tolerability, and pharmacokinetics of MOXR0916 administered intravenously in participants with locally advanced or metastatic solid tumors that have progressed after all available standard therapy or for which standard therapy has proven to be ineffective or intolerable, or is considered inappropriate. This study will consist of a screening period, an initial treatment period, a re-treatment period (for participants who discontinue MOXR0916 after demonstration of prolonged clinical benefit), and a post-treatment follow-up period. Participants will be enrolled in two stages: a dose-escalation stage and an expansion stage. The planned duration of the study is approximately 3 years.

Conditions Studied

Interventions

  • DRUG MOXR0916

Study Locations (20)

Massachusetts

  • Massachusetts General Hospital — Boston
  • Beth Israel Deaconess Medical Center — Boston
  • Dana Farber Can Ins — Boston

Other

  • Institut Jules Bordet — Brussels
  • UZ Gent — Ghent
  • Sint Augustinus Wilrijk — Wilrijk

Victoria

  • Austin Hospital — Heidelberg
  • Peter Maccallum Cancer Centre — Melbourne

Arizona

  • HonorHealth Research Institute - Bisgrove — Scottsdale

Colorado

  • University of Colorado — Aurora

Connecticut

  • Yale School of Medicine — New Haven

District of Columbia

  • Georgetown University Medical Center Lombardi Cancer Center — Washington D.C.

Illinois

  • University Of Chicago Medical Center; Section Of Hematology/Oncology — Chicago

Trial Details

FieldValue
Enrollment Target 174 participants
Start Date 2014-08-12
Est. Completion 2019-08-18
Phase Phase 1

Sponsor

Genentech

206 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02219724

The ClinicalTrials.gov registry entry for NCT02219724 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 174 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genentech, which has 206 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Neoplasms appearing as the primary indexed condition, and to 1 intervention — of which MOXR0916 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02219724 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Massachusetts, Other, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02219724 about?

NCT02219724 is a clinical study titled "A Study to Assess Safety and Pharmacokinetics of MOXR0916 in Participants With Locally Advanced or Metastatic Solid Tumors". This is a first-in-human, Phase 1, open-label, multicenter, dose-escalation study designed to evaluate the safety, tolerability, and pharmacokinetics of MOXR0916 administered intravenously in participants with locally advanced or metastatic solid tumors that have progressed after all available stand...

What is the current status of trial NCT02219724?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 174 participants. The study started on 2014-08-12. Estimated completion is 2019-08-18.

What conditions does trial NCT02219724 study?

This clinical trial studies the following conditions: Neoplasms. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02219724?

The interventions under investigation include: MOXR0916 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02219724?

This trial is sponsored by Genentech, which has 206 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02219724 being conducted?

This trial has 20 study locations across Arizona, Colorado, Connecticut, District of Columbia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial