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NCT02218203 · ClinicalTrials.gov registry record · Phase 2
Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial
A Phase 2 study of Spinal Cord Injury and Central Neuropathic Pain, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- Phase 2
- Development phase
- 26
- Enrollment target
- 1
- Study location
NCT02218203: Completed Phase 2 study of Spinal Cord Injury and Central Neuropathic Pain, sponsored by Brigham and Women's Hospital.
NCT02218203 is a Phase 2 study of Spinal Cord Injury and Central Neuropathic Pain that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 26 participants, below the 86-participant average among 99 other Spinal Cord Injury trials with a reported enrollment target (70% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02218203, a Phase 2 study of Spinal Cord Injury and Central Neuropathic Pain, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a larger NIH-funded study to evaluate the analgesic efficacy of multiple dose-combinations of chronic oral (PO) dextromethorphan and intravenous (IV) lidocaine in central neuropathic pain following spinal cord injury.
Primary Outcome
Primary outcome was percent change from baseline in mean pain intensity at Cmax (transformed Gracely Scale; 0-35). Higher values on the Gracely scale represent greater pain intensity; the greater the percent change from baseline in mean pain intensity, the bigger the reduction in pain intensity.
Conditions Studied
Interventions
- DRUG Lidocaine
- DRUG Dextromethorphan
- DRUG Placebo (Dextromethorphan)
- DRUG Placebo (Lidocaine)
Study Locations (1)
Massachusetts
- Translational Pain Research, Brigham and Women's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2003-04 |
| Est. Completion | 2008-01 |
| Phase | Phase 2 |
What the finished NCT02218203 record still lists
NCT02218203 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 86-participant average among 99 other Spinal Cord Injury trials with a reported enrollment target (70% lower).
The record links to 3 conditions, with Spinal Cord Injury appearing as the primary indexed condition, and to 4 interventions - of which Lidocaine is the first listed.
NCT02218203 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT02218203 about?
NCT02218203 is a clinical study titled "Clinical Neuropharmacology of Pain in Spinal Cord Injury- Dextromethorphan/Lidocaine Combination Clinical Trial". This randomized, placebo-controlled, double-blind 4x4 crossover clinical trial was part of a larger NIH-funded study to evaluate the analgesic efficacy of multiple dose-combinations of chronic oral (PO) dextromethorphan and intravenous (IV) lidocaine in central neuropathic pain following spinal cord...
What is the current status of trial NCT02218203?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 26 participants. The study started on 2003-04. Estimated completion is 2008-01.
What conditions does trial NCT02218203 study?
This clinical trial studies the following conditions: Spinal Cord Injury, Central Neuropathic Pain, Allodynia.
What interventions are being tested in trial NCT02218203?
The interventions under investigation include: Lidocaine (DRUG), Dextromethorphan (DRUG), Placebo (Dextromethorphan) (DRUG), Placebo (Lidocaine) (DRUG).
Who is sponsoring clinical trial NCT02218203?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02218203 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Cord Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02218203's enrollment target sits among peer trials
26 49th of 99 higher than 51 of 99 other Spinal Cord Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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