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NCT02213575 · ClinicalTrials.gov registry record · Phase 2

Study 3: Minocycline Decreases Microglia Activation

A Phase 2 study of Hypertension, sponsored by University of Florida.

Compiled by PlainTrial · August 8, 2026

Completed
Registry status: Phase 2
Development phase: 5
Enrollment target: 1
Study location

NCT02213575: Completed Phase 2 study of Hypertension, sponsored by University of Florida.

NCT02213575 is a Phase 2 study of Hypertension that has completed, run by University of Florida. The registered enrollment target is 5 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT02213575, a Phase 2 study of Hypertension, has completed, sponsored by University of Florida.

COMPLETED
Registry status: Phase 2
Development phase: 5 participants
Enrollment target: 1
Study location

Study Summary

This study is a mechanistic study that will enroll 9 subjects who are participating in NCT02133872 (which is designed to evaluate minocycline to test the hypothesis that minocycline treatment would produce antihypertensive effects in drug-resistant neurogenic hypertensive individuals) to test whether the antihypertensive effect of minocycline is associated with a decrease in activated microglia in central nervous system autonomic regions as evidenced by changes in PET and MRI imaging.

Primary Outcome

This outcome represents the change in PET signal intensity in the bilateral paraventricular nucleus before and after minocycline treatment. PET imaging was performed using the radiotracer \[¹¹C\]PBR28, which binds to the Translocator Protein (TSPO), a marker of activated microglia and neuroinflammation. To ensure accurate anatomical localization, each participant's PET scan was co-registered with a high-resolution T1-weighted MRI. Regions of interest (ROIs) were manually drawn on the MRI and app

Conditions Studied

Hypertension

Interventions

DRUG Minocycline

Study Locations (1)

Florida

UF Health Cardiovascular Clinic - Gainesville

Trial Details

Field	Value
Enrollment Target	5 participants
Start Date	2016-03-05
Est. Completion	2018-11-01
Phase	Phase 2

University of Florida

1,106 total trials

What the finished NCT02213575 record still lists

NCT02213575 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (100% lower).

The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 1 intervention - of which Minocycline is the first listed.

NCT02213575 reports a single indexed study location in Florida.

Frequently Asked Questions

What is clinical trial NCT02213575 about?

NCT02213575 is a clinical study titled "Study 3: Minocycline Decreases Microglia Activation". This study is a mechanistic study that will enroll 9 subjects who are participating in NCT02133872 (which is designed to evaluate minocycline to test the hypothesis that minocycline treatment would produce antihypertensive effects in drug-resistant neurogenic hypertensive individuals) to test whethe...

What is the current status of trial NCT02213575?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 5 participants. The study started on 2016-03-05. Estimated completion is 2018-11-01.

What conditions does trial NCT02213575 study?

This clinical trial studies the following conditions: Hypertension.

What interventions are being tested in trial NCT02213575?

The interventions under investigation include: Minocycline (DRUG).

Who is sponsoring clinical trial NCT02213575?

This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT02213575 being conducted?

This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Hypertension

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT02213575's enrollment target sits among peer trials

5 469th of 470 higher than 1 of 470 other Hypertension trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Source: ClinicalTrials.gov NCT02213575, the US trial registry maintained by the National Library of Medicine. NCT02213575 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.