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NCT02193204 · ClinicalTrials.gov registry record · NA
Chronic Alcohol, Stress Inflammatory Response and Relapse Risk
A NA study of Alcohol Dependence and Depressive Symptomatology, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 116
- Enrollment target
- 1
- Study location
NCT02193204: Completed NA study of Alcohol Dependence and Depressive Symptomatology, sponsored by Yale University.
NCT02193204 is a NA study of Alcohol Dependence and Depressive Symptomatology that has completed, run by Yale University. The registered enrollment target is 116 participants, below the 311-participant average among 43 other Alcohol Dependence trials with a reported enrollment target (63% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02193204, a NA study of Alcohol Dependence and Depressive Symptomatology, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 116 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to examine potential stress and immune systems adaptations underlying craving and relapse vulnerability in alcohol dependent (AD) individuals and social drinkers (SDs) with and without high levels of depressive symptomatology (+dep / - dep). Using the investigators experimentally validated guided imagery procedure, the investigators propose to examine the response of brain stress and immune systems to personalized guided stressful imagery using subjective, physiological and neurobiological assessments in 60 healthy controls and 60 alcoholic dependent individuals with and without depressive symptomatology.
Primary Outcome
At each of the six time-points (-25, -5, +5, +15, +30, +45), serum cytokine concentrations of IL-6, TNFa, TNFR1, IL-10, IL1-ra, IL-4, IL1beta, and IL-12 will be collected. Levels will be determined by enzyme-linked immuno-sorbent assays using the DuoSet ELISA Development Kit from R\&D systems (Minneapolis, MN, USA). Plasma Cortisol and ACTH levels will also be colected and assays will be measured using standard radioimmunoassay procedures.
Conditions Studied
Interventions
- BEHAVIORAL Personal Stress Imagery
- BEHAVIORAL Neutral Imagery
Study Locations (1)
Connecticut
- CT Mental Health Center - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 116 participants |
| Start Date | 2011-09 |
| Est. Completion | 2015-07 |
| Phase | NA |
What the finished NCT02193204 record still lists
NCT02193204 is an interventional study that assigns participants to a tested intervention. The registered 116 participants enrollment target is mid-sized for trials with a published cap, below the 311-participant average among 43 other Alcohol Dependence trials with a reported enrollment target (63% lower).
The record links to 2 conditions, with Alcohol Dependence appearing as the primary indexed condition, and to 2 interventions - of which Personal Stress Imagery is the first listed.
NCT02193204 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT02193204 about?
NCT02193204 is a clinical study titled "Chronic Alcohol, Stress Inflammatory Response and Relapse Risk". The purpose of this study is to examine potential stress and immune systems adaptations underlying craving and relapse vulnerability in alcohol dependent (AD) individuals and social drinkers (SDs) with and without high levels of depressive symptomatology (+dep / - dep). Using the investigators exper...
What is the current status of trial NCT02193204?
This trial is currently completed. It is a NA study. The enrollment target is 116 participants. The study started on 2011-09. Estimated completion is 2015-07.
What conditions does trial NCT02193204 study?
This clinical trial studies the following conditions: Alcohol Dependence, Depressive Symptomatology.
What interventions are being tested in trial NCT02193204?
The interventions under investigation include: Personal Stress Imagery (BEHAVIORAL), Neutral Imagery (BEHAVIORAL).
Who is sponsoring clinical trial NCT02193204?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02193204 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02193204's enrollment target sits among peer trials
116 17th of 43 higher than 27 of 43 other Alcohol Dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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