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NCT02159755 · ClinicalTrials.gov registry record · Phase 1
Ibrutinib and Palbociclib in Treating Patients With Previously Treated Mantle Cell Lymphoma
A Phase 1 study of Recurrent Mantle Cell Lymphoma, sponsored by National Cancer Institute (NCI).
- Active
- Registry status
- Phase 1
- Development phase
- 28
- Enrollment target
- 4
- Study locations
NCT02159755: Active Phase 1 study of Recurrent Mantle Cell Lymphoma, sponsored by National Cancer Institute (NCI).
NCT02159755 is a Phase 1 study of Recurrent Mantle Cell Lymphoma that is active but no longer recruiting, run by National Cancer Institute (NCI). The registered enrollment target is 28 participants, below the 37-participant average among 27 other Recurrent Mantle Cell Lymphoma trials with a reported enrollment target (24% lower). The trial reports 4 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02159755, a Phase 1 study of Recurrent Mantle Cell Lymphoma, is active but no longer recruiting, sponsored by National Cancer Institute (NCI).
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 28 participants
- Enrollment target
- 4
- Study locations
Study Summary
This phase I trial studies the side effects and best dose of ibrutinib and palbociclib in treating patients with previously treated mantle cell lymphoma. Ibrutinib and palbociclib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Palbociclib may also help ibrutinib work better by making cancer cells more sensitive to the drug.
Primary Outcome
Will be defined as the highest dose level at which no more than 1/6 patients present with a dose limiting toxicity (DLT). DLT will be assessed according to the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.
Conditions Studied
Interventions
- OTHER Laboratory Biomarker Analysis
- DRUG Palbociclib
- DRUG Ibrutinib
- OTHER Pharmacological Study
Study Locations (4)
Missouri
- Washington University School of Medicine - St Louis
New York
- NYP/Weill Cornell Medical Center - New York
North Carolina
- UNC Lineberger Comprehensive Cancer Center - Chapel Hill
Ohio
- Ohio State University Comprehensive Cancer Center - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2014-08-13 |
| Est. Completion | 2026-12-01 |
| Phase | Phase 1 |
What the registry record for NCT02159755 still lists
NCT02159755 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 28 participants, a relatively small participant target, below the 37-participant average among 27 other Recurrent Mantle Cell Lymphoma trials with a reported enrollment target (24% lower).
The record links to 1 condition, with Recurrent Mantle Cell Lymphoma appearing as the primary indexed condition, and to 4 interventions - of which Laboratory Biomarker Analysis is the first listed.
NCT02159755 reports a single indexed study location in Missouri, New York, North Carolina.
Frequently Asked Questions
What is clinical trial NCT02159755 about?
NCT02159755 is a clinical study titled "Ibrutinib and Palbociclib in Treating Patients With Previously Treated Mantle Cell Lymphoma". This phase I trial studies the side effects and best dose of ibrutinib and palbociclib in treating patients with previously treated mantle cell lymphoma. Ibrutinib and palbociclib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Palbociclib may also help ib...
What is the current status of trial NCT02159755?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 28 participants. The study started on 2014-08-13. Estimated completion is 2026-12-01.
What conditions does trial NCT02159755 study?
This clinical trial studies the following conditions: Recurrent Mantle Cell Lymphoma.
What interventions are being tested in trial NCT02159755?
The interventions under investigation include: Laboratory Biomarker Analysis (OTHER), Palbociclib (DRUG), Ibrutinib (DRUG), Pharmacological Study (OTHER).
Who is sponsoring clinical trial NCT02159755?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02159755 being conducted?
This trial has 4 study locations across Missouri, New York, North Carolina, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Recurrent Mantle Cell Lymphoma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02159755's enrollment target sits among peer trials
28 15th of 27 higher than 12 of 27 other Recurrent Mantle Cell Lymphoma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Recurrent Mantle Cell Lymphoma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Pacritinib in Combination With a BTK Inhibitor for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma
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Rituxan/Bendamustine/PCI-32765 in Relapsed DLBCL, MCL, or Indolent Non-Hodgkin's Lymphoma
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