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NCT02022280 · ClinicalTrials.gov registry record · Phase 1
Effect of Proton Pump Inhibitors on Endothelial Function
A Phase 1 study, sponsored by Stanford University.
- Completed
- Registry status
- Phase 1
- Development phase
- 21
- Enrollment target
NCT02022280: Completed Phase 1 study, sponsored by Stanford University.
NCT02022280 is a Phase 1 study that has completed, run by Stanford University. The registered enrollment target is 21 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (65% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02022280, a Phase 1 study, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 21 participants
- Enrollment target
Study Summary
In this randomized controlled crossover study, the investigators propose to test the hypothesis that proton pump inhibitors (PPIs) increase plasma levels of asymmetric dimethylarginine (ADMA), which is a marker of endothelial dysfunction. The authors propose to evaluate ADMA concentrations and vascular function analysis in healthy volunteers and adults with a history of cardiovascular disease given PPI vs placebo for four weeks each.
Interventions
- DRUG Placebo
- DRUG Lansoprazole
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2013-03 |
| Est. Completion | 2014-05 |
| Phase | Phase 1 |
What the finished NCT02022280 record still lists
NCT02022280 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (65% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT02022280 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02022280 about?
NCT02022280 is a clinical study titled "Effect of Proton Pump Inhibitors on Endothelial Function". In this randomized controlled crossover study, the investigators propose to test the hypothesis that proton pump inhibitors (PPIs) increase plasma levels of asymmetric dimethylarginine (ADMA), which is a marker of endothelial dysfunction. The authors propose to evaluate ADMA concentrations and vascu...
What is the current status of trial NCT02022280?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 21 participants. The study started on 2013-03. Estimated completion is 2014-05.
What interventions are being tested in trial NCT02022280?
The interventions under investigation include: Placebo (DRUG), Lansoprazole (DRUG).
Who is sponsoring clinical trial NCT02022280?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02022280's enrollment target sits among peer trials
21 1615th of 2000 higher than 372 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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