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NCT01996449 · ClinicalTrials.gov registry record · Phase 2
The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
A Phase 2 study, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- Phase 2
- Development phase
- 14
- Enrollment target
NCT01996449: Completed Phase 2 study, sponsored by University of Texas Southwestern Medical Center.
NCT01996449 is a Phase 2 study that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 14 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01996449, a Phase 2 study, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 14 participants
- Enrollment target
Study Summary
Hypertensive patients often show an exaggerated rise in blood pressure during exercise through overactivity of the exercise pressor reflex. An increasing body of evidence suggests a role for aldosterone in augmenting the exercise pressor reflex in hypertensive humans. We hypothesize that this effect of aldosterone is mediated by its direct action on the central nervous system and that administration of mineralocorticoid receptor antagonists constitute an effective treatment for EPR overactivity in hypertension, independent of reductions in resting BP.
Primary Outcome
measurement of sympathetic nerve activity by microneurography (intraneural microelectrodes)
Interventions
- DRUG Amlodipine
- DRUG Eplerenone
- PROCEDURE Microneurography
- PROCEDURE Rhythmic handgrip exercise
- PROCEDURE Sustained hand grip
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2013-07 |
| Est. Completion | 2021-04 |
| Phase | Phase 2 |
What the finished NCT01996449 record still lists
NCT01996449 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 5 interventions - of which Amlodipine is the first listed.
NCT01996449 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01996449 about?
NCT01996449 is a clinical study titled "The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension". Hypertensive patients often show an exaggerated rise in blood pressure during exercise through overactivity of the exercise pressor reflex. An increasing body of evidence suggests a role for aldosterone in augmenting the exercise pressor reflex in hypertensive humans. We hypothesize that this effect...
What is the current status of trial NCT01996449?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 14 participants. The study started on 2013-07. Estimated completion is 2021-04.
What interventions are being tested in trial NCT01996449?
The interventions under investigation include: Amlodipine (DRUG), Eplerenone (DRUG), Microneurography (PROCEDURE), Rhythmic handgrip exercise (PROCEDURE), Sustained hand grip (PROCEDURE).
Who is sponsoring clinical trial NCT01996449?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01996449's enrollment target sits among peer trials
14 1941st of 2000 higher than 54 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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