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NCT01996449 · ClinicalTrials.gov registry record · Phase 2
The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
A Phase 2 study, sponsored by University of Texas Southwestern Medical Center.
- Completed
- Registry status
- Phase 2
- Development phase
- 14
- Enrollment target
NCT01996449 is a Phase 2 study that has completed, run by University of Texas Southwestern Medical Center. The registered enrollment target is 14 participants.
The verdict
NCT01996449, a Phase 2 study, has completed, sponsored by University of Texas Southwestern Medical Center.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 14 participants
- Enrollment target
Study Summary
Hypertensive patients often show an exaggerated rise in blood pressure during exercise through overactivity of the exercise pressor reflex. An increasing body of evidence suggests a role for aldosterone in augmenting the exercise pressor reflex in hypertensive humans. We hypothesize that this effect of aldosterone is mediated by its direct action on the central nervous system and that administration of mineralocorticoid receptor antagonists constitute an effective treatment for EPR overactivity in hypertension, independent of reductions in resting BP.
Interventions
- DRUG Amlodipine
- DRUG Eplerenone
- PROCEDURE Microneurography
- PROCEDURE Rhythmic handgrip exercise
- PROCEDURE Sustained hand grip
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2013-07 |
| Est. Completion | 2021-04 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01996449
The ClinicalTrials.gov registry entry for NCT01996449 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of Texas Southwestern Medical Center, which has 837 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Amlodipine is the first listed.
NCT01996449 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01996449 about?
NCT01996449 is a clinical study titled "The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension". Hypertensive patients often show an exaggerated rise in blood pressure during exercise through overactivity of the exercise pressor reflex. An increasing body of evidence suggests a role for aldosterone in augmenting the exercise pressor reflex in hypertensive humans. We hypothesize that this effect...
What is the current status of trial NCT01996449?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 14 participants. The study started on 2013-07. Estimated completion is 2021-04.
What interventions are being tested in trial NCT01996449?
The interventions under investigation include: Amlodipine (DRUG), Eplerenone (DRUG), Microneurography (PROCEDURE), Rhythmic handgrip exercise (PROCEDURE), Sustained hand grip (PROCEDURE).
Who is sponsoring clinical trial NCT01996449?
This trial is sponsored by University of Texas Southwestern Medical Center, which has 837 total clinical trials registered on ClinicalTrials.gov.
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