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NCT01913548 · ClinicalTrials.gov registry record

Multi-Center Study of Iron Overload: Survey Study (MCSIO)

A clinical trial of Sickle Cell Disease and Thalassemia, sponsored by UCSF Benioff Children's Hospital Oakland.

Completed
Registry status
423
Enrollment target
8
Study locations

NCT01913548 is a study of Sickle Cell Disease and Thalassemia that has completed, run by UCSF Benioff Children's Hospital Oakland. The registered enrollment target is 423 participants, above the 291-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (45% higher). The trial reports 8 study locations across 7 states.

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The verdict

NCT01913548, a study of Sickle Cell Disease and Thalassemia, has completed, sponsored by UCSF Benioff Children's Hospital Oakland.

COMPLETED
Registry status
423 participants
Enrollment target
8
Study locations

Study Summary

The purpose of this study is to demonstrate that a sufficient number of iron-overloaded thalassemia (THAL), Sickle Cell Disease (SCD)and Diamond Blackfan Anemia (DBA) populations with similar duration of chronic transfusion, and age at start of transfusions would be available for a confirmatory study. The study will examine the hypothesis that a chronic inflammatory state in SCD leads to hepcidin- and cytokine-mediated iron withholding within the RES (reticuloendothelial system), lower plasma NTBI (non-transferrin bound iron) levels, less distribution of iron to the heart in SCD.

Conditions Studied

Sickle Cell Disease Thalassemia Diamond-Blackfan Anemia

Study Locations (8)

Other

  • Universitätsklinikum Hamburg-Eppendorf - Hamburg-Eppendorf
  • UCL Cancer Institute - London

California

  • Children's Hospital & Research Center Oakland - Oakland

Georgia

  • Georgia Regents University - Augusta

Illinois

  • Children's Memorial Hospital - Chicago

North Carolina

  • Adult Comprehensive Sickle Cell Center, Duke University Medical Center - Durham

Pennsylvania

  • Thomas Jefferson SCD Program - Philadelphia

Tennessee

  • St. Jude Children's Research Hospital - Memphis

Trial Details

FieldValue
Enrollment Target 423 participants
Start Date 2010-03-31
Est. Completion 2013-10-31

Sponsor

UCSF Benioff Children's Hospital Oakland

52 total trials

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What the Registry Record Tells You About NCT01913548

The ClinicalTrials.gov registry entry for NCT01913548 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 423 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 291-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (45% higher). The listed sponsor is UCSF Benioff Children's Hospital Oakland, which has 52 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Sickle Cell Disease appearing as the primary indexed condition, and to 0 interventions.

NCT01913548 reports 8 study locations spanning 7 distinct geographic areas - top geographies include Other, California, Georgia.

Frequently Asked Questions

What is clinical trial NCT01913548 about?

NCT01913548 is a clinical study titled "Multi-Center Study of Iron Overload: Survey Study (MCSIO)". The purpose of this study is to demonstrate that a sufficient number of iron-overloaded thalassemia (THAL), Sickle Cell Disease (SCD)and Diamond Blackfan Anemia (DBA) populations with similar duration of chronic transfusion, and age at start of transfusions would be available for a confirmatory stud...

What is the current status of trial NCT01913548?

This trial is currently completed. The enrollment target is 423 participants. The study started on 2010-03-31. Estimated completion is 2013-10-31.

What conditions does trial NCT01913548 study?

This clinical trial studies the following conditions: Sickle Cell Disease, Thalassemia, Diamond-Blackfan Anemia.

Who is sponsoring clinical trial NCT01913548?

This trial is sponsored by UCSF Benioff Children's Hospital Oakland, which has 52 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT01913548 being conducted?

This trial has 8 study locations across California, Georgia, Illinois, North Carolina, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.