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Phase 1 Study of ATR-101 in Subjects With Advanced Adrenocortical Carcinoma
NCT01898715 · View on ClinicalTrials.gov ↗
Study Summary
This first-in-human study is designed to establish the safety and tolerability of ATR-101 in patients with advanced adrenocortical carcinoma whose tumor has progressed on standard therapy. Information will also be collected to determine how long ATR-101 stays in the blood, and if any effect on tumor progression is seen. Biomarkers (blood and urine tests) will determine if any effects on production of steroid hormones (cortisol, aldosterone, estrogen and testosterone) are seen.
Conditions Studied
Interventions
- DRUG ATR-101
Study Locations (5)
Florida
- Moffitt Cancer Center — Tampa
Maryland
- National Institutes of Health/National Cancer Institute — Bethesda
Michigan
- University of Michigan Cancer Center — Ann Arbor
Texas
- MDAnderson Cancer Center — Houston
Other
- Comprehensive Cancer Center Mainfranken, University Hospital of Würzburg — Würzburg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 63 participants |
| Start Date | 2013-08-13 |
| Est. Completion | 2017-10-17 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01898715
The ClinicalTrials.gov registry entry for NCT01898715 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 63 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Millendo Therapeutics, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Adrenocortical Carcinoma appearing as the primary indexed condition, and to 1 intervention — of which ATR-101 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT01898715 reports 5 study locations spanning 5 distinct geographic areas — top geographies include Florida, Maryland, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT01898715 about?
NCT01898715 is a clinical study titled "Phase 1 Study of ATR-101 in Subjects With Advanced Adrenocortical Carcinoma". This first-in-human study is designed to establish the safety and tolerability of ATR-101 in patients with advanced adrenocortical carcinoma whose tumor has progressed on standard therapy. Information will also be collected to determine how long ATR-101 stays in the blood, and if any effect on tumor...
What is the current status of trial NCT01898715?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 63 participants. The study started on 2013-08-13. Estimated completion is 2017-10-17.
What conditions does trial NCT01898715 study?
This clinical trial studies the following conditions: Adrenocortical Carcinoma, ACC, Adrenal Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT01898715?
The interventions under investigation include: ATR-101 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT01898715?
This trial is sponsored by Millendo Therapeutics, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT01898715 being conducted?
This trial has 5 study locations across Florida, Maryland, Michigan, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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