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NCT01849419 · ClinicalTrials.gov registry record · NA
Effects of MDMA on Social and Emotional Processing
A NA study of Drug Addiction, sponsored by University of Chicago.
- Completed
- Registry status
- NA
- Development phase
- 65
- Enrollment target
- 1
- Study location
NCT01849419: Completed NA study of Drug Addiction, sponsored by University of Chicago.
NCT01849419 is a NA study of Drug Addiction that has completed, run by University of Chicago. The registered enrollment target is 65 participants, below the 103-participant average among 13 other Drug Addiction trials with a reported enrollment target (37% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01849419, a NA study of Drug Addiction, has completed, sponsored by University of Chicago.
- COMPLETED
- Registry status
- NA
- Development phase
- 65 participants
- Enrollment target
- 1
- Study location
Study Summary
The main aim of the study is to investigate the effects of ±3,4-methylenedioxymethamphetamine (MDMA; ecstasy) on social and emotional processing in healthy humans. Ecstasy is a widely used recreational drug, with over 2 million Americans reporting use of the drug in 2006. With this number of users, and evidence that high doses of MDMA are neurotoxic in laboratory animals, the public health implications of ecstasy use may be substantial. Certain subjective effects of this drug distinguish it from other stimulants, and may contribute to its widespread use: That is, users report that ecstasy produces profound feelings of empathy and closeness to others. These so-called 'empathogenic' effects, which may reflect the distinctive neurochemical profile of action of the drug, have yet to be characterized in controlled laboratory studies. The investigators propose to characterize the effects of MDMA on measures of social and emotional processing that may contribute to this 'empathogenic' profile, including measures of emotion recognition, emotional responsiveness and sociability. The investigators will assess effects of MDMA (0, 0.75 and 1.5 mg/kg up to 125 mg) one active control drug (oxytocin: 20 IU) in 100 volunteers who report some prior ecstasy use. Oxytocin will be used because it appears to produce pro-social behavioral effects resembling those attributed to MDMA.
Primary Outcome
Participants complete the Dynamic Emotional Identification Task, or DEIT (Wardle et al. 2012) following MDMA, oxytocin or placebo administration during which they identify emotional facial expressions presented on the screen. Participants completed this task once during each of the sessions. In the DEIT, 10 actors performed angry, fearful, sad, and happy expressions, for a total of 40 sequences, which were presented in random order. Each sequence consisted of 50 "frames" progressing from 0 to 1
Conditions Studied
Interventions
- DRUG Within-subjects (MDMA)
- DRUG Within-subjects (oxytocin)
- DRUG Within-subjects (placebo)
Study Locations (1)
Illinois
- University of Chicago - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 65 participants |
| Start Date | 2010-07 |
| Est. Completion | 2013-03 |
| Phase | NA |
What the finished NCT01849419 record still lists
NCT01849419 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 65 participants, a relatively small participant target, below the 103-participant average among 13 other Drug Addiction trials with a reported enrollment target (37% lower).
The record links to 1 condition, with Drug Addiction appearing as the primary indexed condition, and to 3 interventions - of which Within-subjects (MDMA) is the first listed.
NCT01849419 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT01849419 about?
NCT01849419 is a clinical study titled "Effects of MDMA on Social and Emotional Processing". The main aim of the study is to investigate the effects of ±3,4-methylenedioxymethamphetamine (MDMA; ecstasy) on social and emotional processing in healthy humans. Ecstasy is a widely used recreational drug, with over 2 million Americans reporting use of the drug in 2006. With this number of users, ...
What is the current status of trial NCT01849419?
This trial is currently completed. It is a NA study. The enrollment target is 65 participants. The study started on 2010-07. Estimated completion is 2013-03.
What conditions does trial NCT01849419 study?
This clinical trial studies the following conditions: Drug Addiction.
What interventions are being tested in trial NCT01849419?
The interventions under investigation include: Within-subjects (MDMA) (DRUG), Within-subjects (oxytocin) (DRUG), Within-subjects (placebo) (DRUG).
Who is sponsoring clinical trial NCT01849419?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01849419 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01849419's enrollment target sits among peer trials
65 10th of 13 higher than 4 of 13 other Drug Addiction trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Drug Addiction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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