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NCT01849419 · ClinicalTrials.gov registry record · NA

Effects of MDMA on Social and Emotional Processing

A NA study of Drug Addiction, sponsored by University of Chicago.

Completed
Registry status
NA
Development phase
65
Enrollment target
1
Study location

NCT01849419 is a NA study of Drug Addiction that has completed, run by University of Chicago. The registered enrollment target is 65 participants, below the 103-participant average among 13 other Drug Addiction trials with a reported enrollment target (37% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT01849419, a NA study of Drug Addiction, has completed, sponsored by University of Chicago.

COMPLETED
Registry status
NA
Development phase
65 participants
Enrollment target
1
Study location

Study Summary

The main aim of the study is to investigate the effects of ±3,4-methylenedioxymethamphetamine (MDMA; ecstasy) on social and emotional processing in healthy humans. Ecstasy is a widely used recreational drug, with over 2 million Americans reporting use of the drug in 2006. With this number of users, and evidence that high doses of MDMA are neurotoxic in laboratory animals, the public health implications of ecstasy use may be substantial. Certain subjective effects of this drug distinguish it from other stimulants, and may contribute to its widespread use: That is, users report that ecstasy produces profound feelings of empathy and closeness to others. These so-called 'empathogenic' effects, which may reflect the distinctive neurochemical profile of action of the drug, have yet to be characterized in controlled laboratory studies. The investigators propose to characterize the effects of MDMA on measures of social and emotional processing that may contribute to this 'empathogenic' profile, including measures of emotion recognition, emotional responsiveness and sociability. The investigators will assess effects of MDMA (0, 0.75 and 1.5 mg/kg up to 125 mg) one active control drug (oxytocin: 20 IU) in 100 volunteers who report some prior ecstasy use. Oxytocin will be used because it appears to produce pro-social behavioral effects resembling those attributed to MDMA.

Conditions Studied

Drug Addiction

Interventions

  • DRUG Within-subjects (MDMA)
  • DRUG Within-subjects (oxytocin)
  • DRUG Within-subjects (placebo)

Study Locations (1)

Illinois

  • University of Chicago - Chicago

Trial Details

FieldValue
Enrollment Target 65 participants
Start Date 2010-07
Est. Completion 2013-03
Phase NA

Sponsor

University of Chicago

796 total trials

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What the Registry Record Tells You About NCT01849419

The ClinicalTrials.gov registry entry for NCT01849419 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 65 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 103-participant average among 13 other Drug Addiction trials with a reported enrollment target (37% lower). The listed sponsor is University of Chicago, which has 796 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Drug Addiction appearing as the primary indexed condition, and to 3 interventions - of which Within-subjects (MDMA) is the first listed.

NCT01849419 reports 1 study location spanning 1 distinct geographic area - top geographies include Illinois.

Frequently Asked Questions

What is clinical trial NCT01849419 about?

NCT01849419 is a clinical study titled "Effects of MDMA on Social and Emotional Processing". The main aim of the study is to investigate the effects of ±3,4-methylenedioxymethamphetamine (MDMA; ecstasy) on social and emotional processing in healthy humans. Ecstasy is a widely used recreational drug, with over 2 million Americans reporting use of the drug in 2006. With this number of users, ...

What is the current status of trial NCT01849419?

This trial is currently completed. It is a NA study. The enrollment target is 65 participants. The study started on 2010-07. Estimated completion is 2013-03.

What conditions does trial NCT01849419 study?

This clinical trial studies the following conditions: Drug Addiction.

What interventions are being tested in trial NCT01849419?

The interventions under investigation include: Within-subjects (MDMA) (DRUG), Within-subjects (oxytocin) (DRUG), Within-subjects (placebo) (DRUG).

Who is sponsoring clinical trial NCT01849419?

This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT01849419 being conducted?

This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.