Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01820117 · ClinicalTrials.gov registry record
Brain Integrity in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 416
- Enrollment target
NCT01820117 is a clinical trial that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 416 participants.
The verdict
NCT01820117 has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 416 participants
- Enrollment target
Study Summary
While thoracic radiation therapy (TRT) has been a primary component in successful treatment of a variety of childhood and adult cancers, the exposure to this treatment has been associated with significant cardiovascular and pulmonary morbidity in long-term survivors. Within non-cancer populations, cardiovascular and pulmonary morbidity is associated with increased risk for cerebral vascular accidents (CVAs), accelerated brain atrophy and neurocognitive impairment. Patients with chronic heart disease demonstrate problems with attention, processing speed, memory, and executive functions. Chronic pulmonary disease also increases the risk of stroke, leukoencephalopathy, and neurocognitive impairment in non-cancer populations. The investigators propose to examine indices of brain integrity, including neurocognitive performance and brain MRI/MRA, in long-term adult survivors of Hodgkin lymphoma (HL) treated with thoracic radiation and no direct central nervous system therapy. OBJECTIVES: 1. To evaluate brain integrity in adult survivors of childhood HL treated with thoracic radiation therapy. 2. To identify therapeutic factors associated with brain integrity in adult survivors of childhood HL who are at risk for cardiac and pulmonary morbidity. 3. To examine associations between cardiac, vascular and pulmonary health and brain integrity in adult survivors of childhood HL treated with thoracic radiation.
Interventions
- OTHER Neurocognitive Evaluation
- OTHER Quantitative Brain Imaging
- OTHER Neurologic Evaluation
- OTHER Health Questionnaire
- OTHER Vascular Testing
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 416 participants |
| Start Date | 2013-04-26 |
| Est. Completion | 2018-02-20 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01820117
The ClinicalTrials.gov registry entry for NCT01820117 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 416 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 5 interventions - of which Neurocognitive Evaluation is the first listed.
NCT01820117 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01820117 about?
NCT01820117 is a clinical study titled "Brain Integrity in Survivors of Hodgkin Lymphoma Treated With Thoracic Radiation". While thoracic radiation therapy (TRT) has been a primary component in successful treatment of a variety of childhood and adult cancers, the exposure to this treatment has been associated with significant cardiovascular and pulmonary morbidity in long-term survivors. Within non-cancer populations, c...
What is the current status of trial NCT01820117?
This trial is currently completed. The enrollment target is 416 participants. The study started on 2013-04-26. Estimated completion is 2018-02-20.
What interventions are being tested in trial NCT01820117?
The interventions under investigation include: Neurocognitive Evaluation (OTHER), Quantitative Brain Imaging (OTHER), Neurologic Evaluation (OTHER), Health Questionnaire (OTHER), Vascular Testing (OTHER).
Who is sponsoring clinical trial NCT01820117?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.