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NCT01800864 · ClinicalTrials.gov registry record · NA

Leptin Biology in Adipose Tissue

A NA study of Obesity, sponsored by Mayo Clinic.

Completed
Registry status
NA
Development phase
5
Enrollment target
1
Study location

NCT01800864: Completed NA study of Obesity, sponsored by Mayo Clinic.

NCT01800864 is a NA study of Obesity that has completed, run by Mayo Clinic. The registered enrollment target is 5 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT01800864, a NA study of Obesity, has completed, sponsored by Mayo Clinic.

COMPLETED
Registry status
NA
Development phase
5 participants
Enrollment target
1
Study location

Study Summary

Leptin is a fat hormone which acts in maintaining energy balance. However, leptin levels are high in obese subjects indicating resistance to the actions of leptin. High leptin levels have been associated with increased cardiovascular and metabolic risks, but it is not clear if increased leptin or leptin resistance contributes to the increased cardiovascular risk. Further, even though leptin receptors are present in fat tissue, leptin's role in fat tissue functions are not completely investigated in humans. Based on preliminary data the investigators hypothesize that resistance to leptin action in obese adipose tissue is responsible for altering the expression of adipose tissue proteins which contribute to the development of cardiovascular and metabolic dysfunction. To test this hypothesis the investigators propose a novel study directed at investigating the leptin dependent changes in adipose tissue protein expression using adipose tissue obtained from lean and obese human subjects

Primary Outcome

The effect of leptin on adipose tissue protein expression will be assessed by Western blot method. The adipose tissue biopsy samples will be treated with leptin for 24 hours in sterile culture conditions. After leptin treatment, the tissue will be lysed, proteins will be separated by denatured SDS-PAGE electrophoresis, transferred on a nitrocellulose membrane and changes in specific proteins will be determined using protein-specific antibodies.

Conditions Studied

Obesity

Interventions

  • OTHER obesity

Study Locations (1)

Minnesota

  • Mayo Clinic - Rochester

Trial Details

FieldValue
Enrollment Target 5 participants
Start Date 2011-08
Est. Completion 2016-11
Phase NA
Mayo Clinic

2,844 total trials

What the finished NCT01800864 record still lists

NCT01800864 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (99% lower).

The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 1 intervention - of which obesity is the first listed.

NCT01800864 reports a single indexed study location in Minnesota.

Frequently Asked Questions

What is clinical trial NCT01800864 about?

NCT01800864 is a clinical study titled "Leptin Biology in Adipose Tissue". Leptin is a fat hormone which acts in maintaining energy balance. However, leptin levels are high in obese subjects indicating resistance to the actions of leptin. High leptin levels have been associated with increased cardiovascular and metabolic risks, but it is not clear if increased leptin or le...

What is the current status of trial NCT01800864?

This trial is currently completed. It is a NA study. The enrollment target is 5 participants. The study started on 2011-08. Estimated completion is 2016-11.

What conditions does trial NCT01800864 study?

This clinical trial studies the following conditions: Obesity.

What interventions are being tested in trial NCT01800864?

The interventions under investigation include: obesity (OTHER).

Who is sponsoring clinical trial NCT01800864?

This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT01800864 being conducted?

This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Obesity

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT01800864's enrollment target sits among peer trials

5 1050th of 1053 higher than 1 of 1,053 other Obesity trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Obesity trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT01800864, the US trial registry maintained by the National Library of Medicine. NCT01800864 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.