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NCT01691612 · ClinicalTrials.gov registry record · Phase 2
Role of the Isomerase Pin-1 in the Development and Treatment of Asthma
A Phase 2 study, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- Phase 2
- Development phase
- 14
- Enrollment target
NCT01691612: Completed Phase 2 study, sponsored by Brigham and Women's Hospital.
NCT01691612 is a Phase 2 study that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 14 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01691612, a Phase 2 study, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 14 participants
- Enrollment target
Study Summary
Pin1 is activated in asthmatic airways, increasing cytokine mRNA stability and eosinophil survival. This study is designed to test whether the Pin1 enzyme regulates TLR/IL-1R signal pathways in multiple cells in asthma.
Primary Outcome
Measure Pin1 activity in BAL-derived eosinophils after House Dust Mite (HDM) allergen challenge: Eosinophils post-challenge change from pre-challenge is reported: absolute change = \[eosinophils post (%) - eosinophils pre (%)\]
Interventions
- BIOLOGICAL installation of D. pteronyssinus allergens
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2013-03 |
| Est. Completion | 2015-05 |
| Phase | Phase 2 |
What the finished NCT01691612 record still lists
NCT01691612 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 1 intervention - of which installation of D. pteronyssinus allergens is the first listed.
NCT01691612 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01691612 about?
NCT01691612 is a clinical study titled "Role of the Isomerase Pin-1 in the Development and Treatment of Asthma". Pin1 is activated in asthmatic airways, increasing cytokine mRNA stability and eosinophil survival. This study is designed to test whether the Pin1 enzyme regulates TLR/IL-1R signal pathways in multiple cells in asthma.
What is the current status of trial NCT01691612?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 14 participants. The study started on 2013-03. Estimated completion is 2015-05.
What interventions are being tested in trial NCT01691612?
The interventions under investigation include: installation of D. pteronyssinus allergens (BIOLOGICAL).
Who is sponsoring clinical trial NCT01691612?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01691612's enrollment target sits among peer trials
14 1941st of 2000 higher than 54 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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