Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01681225 · ClinicalTrials.gov registry record · NA
EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures
A NA study, sponsored by Beth Israel Deaconess Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 202
- Enrollment target
NCT01681225: Completed NA study, sponsored by Beth Israel Deaconess Medical Center.
NCT01681225 is a NA study that has completed, run by Beth Israel Deaconess Medical Center. The registered enrollment target is 202 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (86% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01681225, a NA study, has completed, sponsored by Beth Israel Deaconess Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 202 participants
- Enrollment target
Study Summary
This phase II multi-centered, randomized controlled trial of mechanical ventilation directed by esophageal pressure measurement will test the primary hypothesis that using a strategy of maintaining a minimal but positive transpulmonary pressure (Ptp = airway pressure minus pleural pressure) throughout the ventilatory cycle will lead to an improvement in patient survival.
Primary Outcome
The trial will utilize a primary composite endpoint that incorporates death and days off the ventilator at 28 days in such a manner that death constitutes a more serious outcome. Every subject is compared to every other subject in the trial and assigned one number resulting from each comparison. Since mortality outcome is clinically more important, mortality takes precedence over days off the ventilator. The sum of scores for patients in the treatment group is compared to the sum of scores of su
Interventions
- OTHER Esophageal-pressure guided mechanical ventilation
- OTHER High PEEP mechanical ventilation
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 202 participants |
| Start Date | 2012-10-31 |
| Est. Completion | 2018-10-19 |
| Phase | NA |
What the finished NCT01681225 record still lists
NCT01681225 is an interventional study that assigns participants to a tested intervention. The registered 202 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (86% lower).
The record links to 0 conditions, and to 2 interventions - of which Esophageal-pressure guided mechanical ventilation is the first listed.
NCT01681225 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01681225 about?
NCT01681225 is a clinical study titled "EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures". This phase II multi-centered, randomized controlled trial of mechanical ventilation directed by esophageal pressure measurement will test the primary hypothesis that using a strategy of maintaining a minimal but positive transpulmonary pressure (Ptp = airway pressure minus pleural pressure) througho...
What is the current status of trial NCT01681225?
This trial is currently completed. It is a NA study. The enrollment target is 202 participants. The study started on 2012-10-31. Estimated completion is 2018-10-19.
What interventions are being tested in trial NCT01681225?
The interventions under investigation include: Esophageal-pressure guided mechanical ventilation (OTHER), High PEEP mechanical ventilation (OTHER).
Who is sponsoring clinical trial NCT01681225?
This trial is sponsored by Beth Israel Deaconess Medical Center, which has 488 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01681225's enrollment target sits among peer trials
202 505th of 2000 higher than 1,495 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT05272254 · 202 participants · Phase 2
Povidone Iodine Efficacy Study
- NCT05701280 · 202 participants · NA
Pilot/Pivotal Study of DBS+Rehab After Stroke
- NCT05932589 · 202 participants
Neurophysiologic Biomarkers in Rett Syndrome
- NCT06014931 · 202 participants · NA
Telehealth-enhanced Patient-oriented Recovery Trajectory After Intensive Care
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI