Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01671696 · ClinicalTrials.gov registry record
Defining Late Onset Occult Asymptomatic Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy
A clinical trial, sponsored by Connecticut Children's Medical Center.
- Completed
- Registry status
- 80
- Enrollment target
NCT01671696: Completed study, sponsored by Connecticut Children's Medical Center.
NCT01671696 is a clinical trial that has completed, run by Connecticut Children's Medical Center. The registered enrollment target is 80 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01671696 has completed, sponsored by Connecticut Children's Medical Center.
- COMPLETED
- Registry status
- 80 participants
- Enrollment target
Study Summary
The main hypothesis being tested is that magnetic resonance imaging and serologic biomarkers of apoptosis and extracellular matrix remodeling will precede echocardiographic indices of systolic and diastolic function among childhood cancer survivors treated with anthracyclines thus allowing evaluation of new therapies to prevent and manage heart failure in these patients.
Primary Outcome
Changes in T1 mapping-derived relaxation time and left ventricular myocardial peak circumferential and longitudinal strain magnitude and segmental circumferential strain magnitude are present in asymptomatic post-chemotherapy pediatric patients who have normal standard CMRI parameters. Circumferential strain analysis and measurement of the T1 myocardial relaxation time by CMRI may accurately identify occult cardiovascular dysfunction in patients exposed to high dose anthracyclines.
Interventions
- OTHER Cardiac MRI
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2011-11-15 |
| Est. Completion | 2017-10-06 |
What the finished NCT01671696 record still lists
NCT01671696 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 80 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which Cardiac MRI is the first listed.
NCT01671696 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01671696 about?
NCT01671696 is a clinical study titled "Defining Late Onset Occult Asymptomatic Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy". The main hypothesis being tested is that magnetic resonance imaging and serologic biomarkers of apoptosis and extracellular matrix remodeling will precede echocardiographic indices of systolic and diastolic function among childhood cancer survivors treated with anthracyclines thus allowing evaluatio...
What is the current status of trial NCT01671696?
This trial is currently completed. The enrollment target is 80 participants. The study started on 2011-11-15. Estimated completion is 2017-10-06.
What interventions are being tested in trial NCT01671696?
The interventions under investigation include: Cardiac MRI (OTHER).
Who is sponsoring clinical trial NCT01671696?
This trial is sponsored by Connecticut Children's Medical Center, which has 55 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01243931 · 80 participants · NA
Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
- NCT01659203 · 80 participants · Phase 1
Proton or Photon RT for Retroperitoneal Sarcomas
- NCT01803451 · 80 participants · Early Phase 1
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
- NCT01964859 · 80 participants · Phase 2
Feasibility Study for Fibroblast Autologous Skin Grafts
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI