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NCT01588821 · ClinicalTrials.gov registry record · Phase 2
Cabozantinib in Advanced Solid Malignancies
A Phase 2 study of Lung Cancer and Solid Tumor (Not Breast or Prostate Cancers), sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- Phase 2
- Development phase
- 37
- Enrollment target
- 1
- Study location
NCT01588821: Completed Phase 2 study of Lung Cancer and Solid Tumor (Not Breast or Prostate Cancers), sponsored by Massachusetts General Hospital.
NCT01588821 is a Phase 2 study of Lung Cancer and Solid Tumor (Not Breast or Prostate Cancers) that has completed, run by Massachusetts General Hospital. The registered enrollment target is 37 participants, below the 936-participant average among 409 other Lung Cancer trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01588821, a Phase 2 study of Lung Cancer and Solid Tumor (Not Breast or Prostate Cancers), has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 37 participants
- Enrollment target
- 1
- Study location
Study Summary
This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational drug to learn whether the drug works in treating a specific cancer. "Investigational" means that the drug is still being studied and that research doctors are trying to find out more about it-such as the safest dose to use, the side effects it may cause, and if the drug is effective for treating different types of cancer. It also means that the FDA has not approved the drug for this type of cancer, or for any use outside of research studies. When cancer spreads from the primary tumor, one of the most commons sites it spreads to is bone. When cancer spreads to bone there can be significant symptoms such as pain. Cabozantinib works by blocking signaling that leads to cancer growth as well as blocking the growth of new blood vessels (angiogenesis) that help to feed a tumor. Cabozantinib has been studied or is being studied in research studies as a possible treatment for various types of cancer, including prostate cancer, brain cancer, thyroid cancer, lung cancer and kidney cancer. Previous clinical research studies indicate that cabozantinib may also have activity against cancer once it has spread to the bones. The purpose of this study is to find out if cabozantinib is effective in treating cancer that has spread to the bone.
Primary Outcome
Effect of cabozantinib on bone biomarkers of osteoblast and osteoclast activity. The bio-markers of interest were serum C-terminal telopeptide (Ctx), urine N-terminal telopeptide (Ntx), serum (Ntx). Participants were considered to have a response if there was at least a 40% decrease in the bio-marker concentration.
Conditions Studied
Interventions
- DRUG Cabozantinib
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2012-06 |
| Est. Completion | 2019-06 |
| Phase | Phase 2 |
What the finished NCT01588821 record still lists
NCT01588821 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 37 participants, a relatively small participant target, below the 936-participant average among 409 other Lung Cancer trials with a reported enrollment target (96% lower).
The record links to 2 conditions, with Lung Cancer appearing as the primary indexed condition, and to 1 intervention - of which Cabozantinib is the first listed.
NCT01588821 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT01588821 about?
NCT01588821 is a clinical study titled "Cabozantinib in Advanced Solid Malignancies". This research study is a Phase II clinical trial. Phase II clinical trials test the effectiveness of an investigational drug to learn whether the drug works in treating a specific cancer. "Investigational" means that the drug is still being studied and that research doctors are trying to find out mo...
What is the current status of trial NCT01588821?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 37 participants. The study started on 2012-06. Estimated completion is 2019-06.
What conditions does trial NCT01588821 study?
This clinical trial studies the following conditions: Lung Cancer, Solid Tumor (Not Breast or Prostate Cancers).
What interventions are being tested in trial NCT01588821?
The interventions under investigation include: Cabozantinib (DRUG).
Who is sponsoring clinical trial NCT01588821?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01588821 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01588821's enrollment target sits among peer trials
37 307th of 409 higher than 100 of 409 other Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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