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NCT01497483 · ClinicalTrials.gov registry record · Phase 1
Drug-Drug Interaction Study With Pravastatin and Cyclosporine
A Phase 1 study, sponsored by University of California, San Francisco.
- Completed
- Registry status
- Phase 1
- Development phase
- 21
- Enrollment target
NCT01497483: Completed Phase 1 study, sponsored by University of California, San Francisco.
NCT01497483 is a Phase 1 study that has completed, run by University of California, San Francisco. The registered enrollment target is 21 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (65% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01497483, a Phase 1 study, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 21 participants
- Enrollment target
Study Summary
This study will address the following question: Does cyclosporine affect the pharmacokinetics of pravastatin in healthy volunteers? Studies have shown that cyclosporine inhibits the organic anion transporter required for pravastatin transport into the liver, thus increasing pravastatin levels in the blood. The investigators hypothesize that this inhibition will vary among people based on genetic differences. This knowledge is important to help develop safer and more effective drug therapy with reduced side effects.
Interventions
- DRUG Pravastatin alone
- DRUG Pravastatin and Cyclosporine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2011-12 |
| Est. Completion | 2013-12 |
| Phase | Phase 1 |
What the finished NCT01497483 record still lists
NCT01497483 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (65% lower).
The record links to 0 conditions, and to 2 interventions - of which Pravastatin alone is the first listed.
NCT01497483 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01497483 about?
NCT01497483 is a clinical study titled "Drug-Drug Interaction Study With Pravastatin and Cyclosporine". This study will address the following question: Does cyclosporine affect the pharmacokinetics of pravastatin in healthy volunteers? Studies have shown that cyclosporine inhibits the organic anion transporter required for pravastatin transport into the liver, thus increasing pravastatin levels in the...
What is the current status of trial NCT01497483?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 21 participants. The study started on 2011-12. Estimated completion is 2013-12.
What interventions are being tested in trial NCT01497483?
The interventions under investigation include: Pravastatin alone (DRUG), Pravastatin and Cyclosporine (DRUG).
Who is sponsoring clinical trial NCT01497483?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01497483's enrollment target sits among peer trials
21 1615th of 2000 higher than 372 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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