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NCT01489475 · ClinicalTrials.gov registry record
Plasma Angiopoietin Levels in Children Following Cardiopulmonary Bypass
A clinical trial, sponsored by Yale University.
- Completed
- Registry status
- 31
- Enrollment target
NCT01489475 is a clinical trial that has completed, run by Yale University. The registered enrollment target is 31 participants.
The verdict
NCT01489475 has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- 31 participants
- Enrollment target
Study Summary
During cardiopulmonary bypass (CPB) after heart surgery, a child's blood is exposed to many foreign entities. These conditions trigger the body's inflammatory response which results in leaky capillaries, increased swelling and possibly organ dysfunction. Since the early 1990's, modified ultrafiltration (MUF) has been shown to decrease excess swelling, reduce bleeding, improve heart function, and decrease hospital length of stay. Angiopoietins are a family of proteins necessary for both normal and abnormal blood vessel formation. They also appear to play a role in capillary leak. Though MUF has been shown to improve clinical outcome following CPB, there continues to be conflicting reports whether this is a result of the filtration of inflammatory proteins or simply from excess fluid removal. Since angiopoietins appear to play a role in both inflammation and capillary leak, the investigators hypothesize that the benefit seen after MUF is also secondary to its ability to filter out these proteins, especially angiopoietin-2.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 31 participants |
| Start Date | 2011-11 |
| Est. Completion | 2013-06 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01489475
The ClinicalTrials.gov registry entry for NCT01489475 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 31 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Yale University, which has 1,492 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT01489475 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01489475 about?
NCT01489475 is a clinical study titled "Plasma Angiopoietin Levels in Children Following Cardiopulmonary Bypass". During cardiopulmonary bypass (CPB) after heart surgery, a child's blood is exposed to many foreign entities. These conditions trigger the body's inflammatory response which results in leaky capillaries, increased swelling and possibly organ dysfunction. Since the early 1990's, modified ultrafiltrat...
What is the current status of trial NCT01489475?
This trial is currently completed. The enrollment target is 31 participants. The study started on 2011-11. Estimated completion is 2013-06.
Who is sponsoring clinical trial NCT01489475?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
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