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NCT01442480 · ClinicalTrials.gov registry record · NA
Cardioprotective Effects of Omega-3 Fatty Acids Supplementation in Healthy Older Subjects Exposed to Air Pollution Particles
A NA study of Healthy, sponsored by Environmental Protection Agency (EPA).
- Completed
- Registry status
- NA
- Development phase
- 29
- Enrollment target
- 1
- Study location
NCT01442480: Completed NA study of Healthy, sponsored by Environmental Protection Agency (EPA).
NCT01442480 is a NA study of Healthy that has completed, run by Environmental Protection Agency (EPA). The registered enrollment target is 29 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01442480, a NA study of Healthy, has completed, sponsored by Environmental Protection Agency (EPA).
- COMPLETED
- Registry status
- NA
- Development phase
- 29 participants
- Enrollment target
- 1
- Study location
Study Summary
Exposure to ambient levels of air pollution increases cardiovascular morbidity and mortality. Advanced age is among the factors associated with susceptibility to the adverse effects of air pollution. Dietary fatty acid supplementation has been shown to decrease cardiovascular risk through multiple mechanisms. This study evaluated the efficacy of supplementation with marine fish oil or olive oil in protecting against cardiovascular effects induced by controlled exposure of middle-aged healthy volunteers to concentrated ambient air pollution particles. Subjects (ages 50 to72 years), were randomly assigned to receive 3 g/d of fish oil (1.2 g eicosapentaenoic acid and 0.82 g docosahexaenoic acid), or olive oil (3g/d) for 28 d. Subjects were then exposed to concentrated ambient air pollution particles or filtered air for 2 hr on sequential days. Heart rate variability (HRV), plasma lipids, coagulation markers, and endothelial function measured by flow-mediated dilation of the brachial artery (FMD) were assessed pre-, immediately post-, and 20 hr post-exposure.
Conditions Studied
Interventions
- DIETARY_SUPPLEMENT Fish oil
- DIETARY_SUPPLEMENT Olive oil
Study Locations (1)
North Carolina
- EPA Human Studies Facility - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2009-06 |
| Est. Completion | 2016-12 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01442480
The ClinicalTrials.gov registry entry for NCT01442480 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (96% lower). The listed sponsor is Environmental Protection Agency (EPA), which has 9 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 2 interventions - of which Fish oil is the first listed.
NCT01442480 reports 1 study location spanning 1 distinct geographic area - top geographies include North Carolina.
Frequently Asked Questions
What is clinical trial NCT01442480 about?
NCT01442480 is a clinical study titled "Cardioprotective Effects of Omega-3 Fatty Acids Supplementation in Healthy Older Subjects Exposed to Air Pollution Particles". Exposure to ambient levels of air pollution increases cardiovascular morbidity and mortality. Advanced age is among the factors associated with susceptibility to the adverse effects of air pollution. Dietary fatty acid supplementation has been shown to decrease cardiovascular risk through multiple m...
What is the current status of trial NCT01442480?
This trial is currently completed. It is a NA study. The enrollment target is 29 participants. The study started on 2009-06. Estimated completion is 2016-12.
What conditions does trial NCT01442480 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT01442480?
The interventions under investigation include: Fish oil (DIETARY_SUPPLEMENT), Olive oil (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01442480?
This trial is sponsored by Environmental Protection Agency (EPA), which has 9 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01442480 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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