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NCT01355965 · ClinicalTrials.gov registry record · Phase 1
Autologous Redirected RNA Meso-CIR T Cells
A Phase 1 study of Malignant Pleural Mesothelioma, sponsored by University of Pennsylvania.
- Completed
- Registry status
- Phase 1
- Development phase
- 18
- Enrollment target
- 1
- Study location
NCT01355965: Completed Phase 1 study of Malignant Pleural Mesothelioma, sponsored by University of Pennsylvania.
NCT01355965 is a Phase 1 study of Malignant Pleural Mesothelioma that has completed, run by University of Pennsylvania. The registered enrollment target is 18 participants, below the 87-participant average among 6 other Malignant Pleural Mesothelioma trials with a reported enrollment target (79% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01355965, a Phase 1 study of Malignant Pleural Mesothelioma, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 18 participants
- Enrollment target
- 1
- Study location
Study Summary
To determine the safety and manufacturing feasibility of IV autologous chimeric immune receptor (CIR) T cells transfected with anti-mesothelin messenger RNA (mRNA) expressing a single chain antibody variable fragment linked to the intracellular CD 3 zeta T cell receptor domain and the 4-1BB costimulatory domain.
Primary Outcome
Occurence of study related adverse events greater than to equal to Grade 3 events that are possibly, likely or definitely related to study treatment.
Conditions Studied
Interventions
- BIOLOGICAL Autologous T cells
Study Locations (1)
Pennsylvania
- Abramson Cancer Center of the University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2011-05 |
| Est. Completion | 2015-10 |
| Phase | Phase 1 |
What the finished NCT01355965 record still lists
NCT01355965 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 87-participant average among 6 other Malignant Pleural Mesothelioma trials with a reported enrollment target (79% lower).
The record links to 1 condition, with Malignant Pleural Mesothelioma appearing as the primary indexed condition, and to 1 intervention - of which Autologous T cells is the first listed.
NCT01355965 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01355965 about?
NCT01355965 is a clinical study titled "Autologous Redirected RNA Meso-CIR T Cells". To determine the safety and manufacturing feasibility of IV autologous chimeric immune receptor (CIR) T cells transfected with anti-mesothelin messenger RNA (mRNA) expressing a single chain antibody variable fragment linked to the intracellular CD 3 zeta T cell receptor domain and the 4-1BB costimul...
What is the current status of trial NCT01355965?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2011-05. Estimated completion is 2015-10.
What conditions does trial NCT01355965 study?
This clinical trial studies the following conditions: Malignant Pleural Mesothelioma.
What interventions are being tested in trial NCT01355965?
The interventions under investigation include: Autologous T cells (BIOLOGICAL).
Who is sponsoring clinical trial NCT01355965?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01355965 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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