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NCT04162015 · ClinicalTrials.gov registry record · Phase 1
A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma
A Phase 1 study of Malignant Pleural Mesothelioma, sponsored by Memorial Sloan Kettering Cancer Center.
- Active
- Registry status
- Phase 1
- Development phase
- 22
- Enrollment target
- 7
- Study locations
NCT04162015: Active Phase 1 study of Malignant Pleural Mesothelioma, sponsored by Memorial Sloan Kettering Cancer Center.
NCT04162015 is a Phase 1 study of Malignant Pleural Mesothelioma that is active but no longer recruiting, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 22 participants, below the 86-participant average among 6 other Malignant Pleural Mesothelioma trials with a reported enrollment target (74% lower). The trial reports 7 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04162015, a Phase 1 study of Malignant Pleural Mesothelioma, is active but no longer recruiting, sponsored by Memorial Sloan Kettering Cancer Center.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 22 participants
- Enrollment target
- 7
- Study locations
Study Summary
This study will test whether giving nivolumab in combination with pemetrexed and either cisplatin or carboplatin before surgery is a safe and effective approach to treating resectable mesothelioma without delaying surgery.
Primary Outcome
Patients who experience a greater than 30 day toxicity induced delay of surgery will be counted as a failure for the primary feasibility endpoint.
Conditions Studied
Interventions
- DRUG Pemetrexed
- DRUG Nivolumab
- DRUG Cisplatin or Carboplatin
Study Locations (7)
New York
- Memorial Sloan Kettering Commack - Commack
- Memorial Sloan Kettering Westchester - Harrison
- Memorial Sloan Kettering Cancer Center - New York
- Memorial Sloan Kettering Nassau - Uniondale
New Jersey
- Memoiral Sloan Kettering Basking Ridge - Basking Ridge
- Memorial Sloan Kettering Monmouth - Middletown
- Memorial Sloan Kettering Bergen - Montvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2019-11-12 |
| Est. Completion | 2026-11 |
| Phase | Phase 1 |
What the registry record for NCT04162015 still lists
NCT04162015 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 22 participants, a relatively small participant target, below the 86-participant average among 6 other Malignant Pleural Mesothelioma trials with a reported enrollment target (74% lower).
The record links to 1 condition, with Malignant Pleural Mesothelioma appearing as the primary indexed condition, and to 3 interventions - of which Pemetrexed is the first listed.
NCT04162015 lists 7 locations in 2 states (New York, New Jersey).
Frequently Asked Questions
What is clinical trial NCT04162015 about?
NCT04162015 is a clinical study titled "A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma". This study will test whether giving nivolumab in combination with pemetrexed and either cisplatin or carboplatin before surgery is a safe and effective approach to treating resectable mesothelioma without delaying surgery.
What is the current status of trial NCT04162015?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 22 participants. The study started on 2019-11-12. Estimated completion is 2026-11.
What conditions does trial NCT04162015 study?
This clinical trial studies the following conditions: Malignant Pleural Mesothelioma.
What interventions are being tested in trial NCT04162015?
The interventions under investigation include: Pemetrexed (DRUG), Nivolumab (DRUG), Cisplatin or Carboplatin (DRUG).
Who is sponsoring clinical trial NCT04162015?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04162015 being conducted?
This trial has 7 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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