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NCT01137253 · ClinicalTrials.gov registry record · Phase 1
Autonomic Nervous System and Nitric Oxide Interactions
A Phase 1 study, sponsored by Vanderbilt University.
- Completed
- Registry status
- Phase 1
- Development phase
- 21
- Enrollment target
NCT01137253: Completed Phase 1 study, sponsored by Vanderbilt University.
NCT01137253 is a Phase 1 study that has completed, run by Vanderbilt University. The registered enrollment target is 21 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (65% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01137253, a Phase 1 study, has completed, sponsored by Vanderbilt University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 21 participants
- Enrollment target
Study Summary
The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects. In particular, the investigators will study how endothelial function (response to intra-arterial acetylcholine) changes during autonomic withdrawal.
Primary Outcome
The dose response curve to intrabrachial vasodilators will be determined using the peak forearm blood flow during the last 5 minutes of each drug infusion
Interventions
- DRUG Placebo
- DRUG Trimethaphan
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2010-06 |
| Est. Completion | 2017-01 |
| Phase | Phase 1 |
What the finished NCT01137253 record still lists
NCT01137253 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (65% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT01137253 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01137253 about?
NCT01137253 is a clinical study titled "Autonomic Nervous System and Nitric Oxide Interactions". The investigators are interested in the role of the autonomic nervous system in the regulation of endothelial function among obese hypertensive subjects. In particular, the investigators will study how endothelial function (response to intra-arterial acetylcholine) changes during autonomic withdrawa...
What is the current status of trial NCT01137253?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 21 participants. The study started on 2010-06. Estimated completion is 2017-01.
What interventions are being tested in trial NCT01137253?
The interventions under investigation include: Placebo (DRUG), Trimethaphan (DRUG).
Who is sponsoring clinical trial NCT01137253?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01137253's enrollment target sits among peer trials
21 1615th of 2000 higher than 372 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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