Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01114958 · ClinicalTrials.gov registry record · Phase 1
Pilot Study of Intra-Arterial Cisplatin With IV Thiosulfate in Patients With Lung Cancer or Lung Metastases
A Phase 1 study of Neoplasm Metastasis and Lung Neoplasms, sponsored by University of California, San Diego.
- Completed
- Registry status
- Phase 1
- Development phase
- 8
- Enrollment target
- 1
- Study location
NCT01114958: Completed Phase 1 study of Neoplasm Metastasis and Lung Neoplasms, sponsored by University of California, San Diego.
NCT01114958 is a Phase 1 study of Neoplasm Metastasis and Lung Neoplasms that has completed, run by University of California, San Diego. The registered enrollment target is 8 participants, below the 416-participant average among 41 other Neoplasm Metastasis trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01114958, a Phase 1 study of Neoplasm Metastasis and Lung Neoplasms, has completed, sponsored by University of California, San Diego.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 8 participants
- Enrollment target
- 1
- Study location
Study Summary
This phase I study proposes the use of systemic thiosulfate rescue to allow supradose intra-arterial cisplatin delivery to lung tumors. Eligible patients would be those with at least one lung lesion large enough of characterize angiographically. All patients will first undergo a CT arteriogram of the target tumor. Patients will then receive 2 treatments on 2 consecutive weeks. The primary endpoint will be toxicity, with secondary endpoint of response as measured on week 4. This pilot study will also determine how technically feasible it is to locate the blood supply to these tumors and deliver cisplatin. If the first 6 patients do well, 6 additional patients will be accrued for a total of 12.
Primary Outcome
To characterize the toxicity of intra-arterial supradose cisplatin with thiosulfate rescue when delivered as two doses, one week apart, for patients with primary lung tumors and/or lung metastases.
Conditions Studied
Interventions
- DRUG Cisplatin, Thiosulfate
Study Locations (1)
California
- University of California, San Diego Moores Cancer Center - La Jolla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2009-09-03 |
| Est. Completion | 2013-05-17 |
| Phase | Phase 1 |
What the finished NCT01114958 record still lists
NCT01114958 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 416-participant average among 41 other Neoplasm Metastasis trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Neoplasm Metastasis appearing as the primary indexed condition, and to 1 intervention - of which Cisplatin, Thiosulfate is the first listed.
NCT01114958 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT01114958 about?
NCT01114958 is a clinical study titled "Pilot Study of Intra-Arterial Cisplatin With IV Thiosulfate in Patients With Lung Cancer or Lung Metastases". This phase I study proposes the use of systemic thiosulfate rescue to allow supradose intra-arterial cisplatin delivery to lung tumors. Eligible patients would be those with at least one lung lesion large enough of characterize angiographically. All patients will first undergo a CT arteriogram of th...
What is the current status of trial NCT01114958?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 8 participants. The study started on 2009-09-03. Estimated completion is 2013-05-17.
What conditions does trial NCT01114958 study?
This clinical trial studies the following conditions: Neoplasm Metastasis, Lung Neoplasms.
What interventions are being tested in trial NCT01114958?
The interventions under investigation include: Cisplatin, Thiosulfate (DRUG).
Who is sponsoring clinical trial NCT01114958?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01114958 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Neoplasm Metastasis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01114958's enrollment target sits among peer trials
8 42nd of 41 the lowest of 41 other Neoplasm Metastasis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Neoplasm Metastasis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
EMB-01 in Patients With Advanced/Metastatic Gastrointestinal Cancers
RECRUITING · Phase 1
-
FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3
RECRUITING · Phase 1
-
A Study of LY4175408 in Participants With Advanced Cancer
RECRUITING · Phase 1
-
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
RECRUITING · Phase 1
-
Dose Finding Study of Zanzalintinib With Pembrolizumab and Cetuximab in Head and Neck SCC
RECRUITING · Phase 1
-
A Study of MK-6837 as a Monotherapy and Combination Therapy in Participants With Advanced/Metastatic Solid Tumors (MK-6837-001)
ACTIVE NOT RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI