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NCT01078467 · ClinicalTrials.gov registry record
The Molecular Anatomy of Oral Wound Healing
A clinical trial, sponsored by National Institute of Dental and Craniofacial Research (NIDCR).
- Completed
- Registry status
- 53
- Enrollment target
NCT01078467: Completed study, sponsored by National Institute of Dental and Craniofacial Research (NIDCR).
NCT01078467 is a clinical trial that has completed, run by National Institute of Dental and Craniofacial Research (NIDCR). The registered enrollment target is 53 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01078467 has completed, sponsored by National Institute of Dental and Craniofacial Research (NIDCR).
- COMPLETED
- Registry status
- 53 participants
- Enrollment target
Study Summary
Background: * Two important properties distinguish the healing process of skin wounds from that of wounds of the mucous membranes of the mouth (oral mucosa). Although the skin and the oral mucosa tissues are similar in nature, oral mucosa have more rapid healing and a lack of scar tissue formation. However, oral wound healing in general has been poorly studied, and more information is needed to determine how specific aspects of the oral environment affect the healing process. * Researchers are interested in identifying various factors that contribute to oral wound healing. Studying this process would help researchers explore procedures to accelerate the healing of critically-sized oral lesions formed by trauma, surgery, radiation therapy, infection, and other damage to the mouth. In addition, research into scar-free healing could be applied to other mucosal sites to promote healing and minimize unsightly scars that may compromise the tissue. Objectives: \- To identify the specific factors that enable rapid and nearly scar-free healing of oral mucosa. Eligibility: * Healthy male volunteers between 18 and 40 years of age. * Regular cigarette, cigar, and pipe smokers; occasional smokers who smoke more than 1 day a week or have smoked in the prior month; users of chewing tobacco or betel nut; and heavy drinkers (three or more alcoholic drinks per day) will be excluded. Design: * Participants will have a medical history and examination, and will provide blood samples at the start of the study. * Participants will provide oral mucosa samples from the inside of the cheek, taken using a dermal punch. At the same time, participants will provide skin biopsy samples of approximately the same size. After the skin and oral mucosa samples are taken, participants will be divided into three groups for follow-up procedures. * Group 1: No further samples will be collected. This group will help document the normal healing process. * Group 2: A second, slightly larger biopsy, wh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 53 participants |
| Start Date | 2010-02-02 |
| Est. Completion | 2019-02-19 |
What the finished NCT01078467 record still lists
NCT01078467 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 53 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01078467 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01078467 about?
NCT01078467 is a clinical study titled "The Molecular Anatomy of Oral Wound Healing". Background: * Two important properties distinguish the healing process of skin wounds from that of wounds of the mucous membranes of the mouth (oral mucosa). Although the skin and the oral mucosa tissues are similar in nature, oral mucosa have more rapid healing and a lack of scar tissue formation....
What is the current status of trial NCT01078467?
This trial is currently completed. The enrollment target is 53 participants. The study started on 2010-02-02. Estimated completion is 2019-02-19.
Who is sponsoring clinical trial NCT01078467?
This trial is sponsored by National Institute of Dental and Craniofacial Research (NIDCR), which has 91 total clinical trials registered on ClinicalTrials.gov.
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