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COMPLETED Phase 2

Belinostat and Carboplatin in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer That Did Not Respond to Carboplatin or Cisplatin

NCT00993616 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial is studying how well giving belinostat together with carboplatin works in treating patients with recurrent or persistent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer that did not respond to carboplatin or cisplatin. Belinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving belinostat together with carboplatin may kill more tumor cells.

Interventions

  • DRUG carboplatin
  • DRUG belinostat

Study Locations (20)

Iowa

  • Medical Oncology and Hematology Associates-West Des Moines — Clive
  • Mercy Cancer Center-West Lakes — Clive
  • Iowa Methodist Medical Center — Des Moines
  • Iowa Oncology Research Association CCOP — Des Moines
  • Medical Oncology and Hematology Associates-Des Moines — Des Moines
  • Medical Oncology and Hematology Associates-Laurel — Des Moines
  • Mercy Medical Center - Des Moines — Des Moines
  • Iowa Lutheran Hospital — Des Moines
  • University of Iowa Hospitals and Clinics — Iowa City
  • Mercy Medical Center-West Lakes — West Des Moines

Kansas

  • Menorah Medical Center — Overland Park
  • Saint Luke's South Hospital — Overland Park
  • Shawnee Mission Medical Center — Shawnee Mission

Connecticut

  • Saint Francis Hospital and Medical Center — Hartford
  • The Hospital of Central Connecticut — New Britain

Delaware

  • Beebe Medical Center — Lewes
  • Christiana Care Health System-Christiana Hospital — Newark

Illinois

  • Rush University Medical Center — Chicago

Indiana

  • Indiana University Medical Center — Indianapolis

Maryland

  • Greater Baltimore Medical Center — Baltimore

Trial Details

FieldValue
Enrollment Target 29 participants
Start Date 2009-12
Est. Completion 2012-07-29
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00993616

The ClinicalTrials.gov registry entry for NCT00993616 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Fallopian Tube Cancer appearing as the primary indexed condition, and to 2 interventions — of which carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00993616 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Iowa, Kansas, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00993616 about?

NCT00993616 is a clinical study titled "Belinostat and Carboplatin in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer That Did Not Respond to Carboplatin or Cisplatin". This phase II trial is studying how well giving belinostat together with carboplatin works in treating patients with recurrent or persistent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer that did not respond to carboplatin or cisplatin. Belinostat may stop the growth...

What is the current status of trial NCT00993616?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 29 participants. The study started on 2009-12. Estimated completion is 2012-07-29.

What conditions does trial NCT00993616 study?

This clinical trial studies the following conditions: Fallopian Tube Cancer, Primary Peritoneal Cavity Cancer, Ovarian Endometrioid Adenocarcinoma, Recurrent Ovarian Epithelial Cancer, Ovarian Mucinous Cystadenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00993616?

The interventions under investigation include: carboplatin (DRUG), belinostat (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00993616?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00993616 being conducted?

This trial has 20 study locations across Connecticut, Delaware, Illinois, Indiana, Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial