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NCT00938964 · ClinicalTrials.gov registry record · NA
Lidocaine For Neuroprotection During Cardiac Surgery
A NA study, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 550
- Enrollment target
NCT00938964: Completed NA study, sponsored by Duke University.
NCT00938964 is a NA study that has completed, run by Duke University. The registered enrollment target is 550 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (61% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00938964, a NA study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 550 participants
- Enrollment target
Study Summary
The purpose of this study is to see if a drug called lidocaine prevents cognitive injury (a decline in mental abilities) after heart surgery. Lidocaine is currently FDA approved and is commonly used for treating some heart rhythm disorders and for regional anesthesia (blocking nerves). The investigators are enrolling subjects in this research project to see if lidocaine will reduce the high incidence of cognitive injury seen after heart surgery. As part of this study, the investigators will also evaluate the relationship between cognitive injury and genetic makeup and the chemical changes in the subjects blood during and after surgery.
Primary Outcome
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative
Interventions
- DRUG Placebo
- DRUG Lidocaine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 550 participants |
| Start Date | 2009-07 |
| Est. Completion | 2017-05-23 |
| Phase | NA |
What the finished NCT00938964 record still lists
NCT00938964 is an interventional study that assigns participants to a tested intervention. The registered 550 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (61% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00938964 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00938964 about?
NCT00938964 is a clinical study titled "Lidocaine For Neuroprotection During Cardiac Surgery". The purpose of this study is to see if a drug called lidocaine prevents cognitive injury (a decline in mental abilities) after heart surgery. Lidocaine is currently FDA approved and is commonly used for treating some heart rhythm disorders and for regional anesthesia (blocking nerves). The investiga...
What is the current status of trial NCT00938964?
This trial is currently completed. It is a NA study. The enrollment target is 550 participants. The study started on 2009-07. Estimated completion is 2017-05-23.
What interventions are being tested in trial NCT00938964?
The interventions under investigation include: Placebo (DRUG), Lidocaine (DRUG).
Who is sponsoring clinical trial NCT00938964?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00938964's enrollment target sits among peer trials
550 184th of 2000 higher than 1,815 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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