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COMPLETED Phase 1

A Study Evaluating Intermittent and Continuous OSI-906 and Weekly Paclitaxel in Patients With Recurrent Epithelial Ovarian Cancer (and Other Solid Tumors)

NCT00889382 · View on ClinicalTrials.gov ↗

Study Summary

This is a multi-center, randomized, open-label, phase 1/2 study of continuous weekly paclitaxel and escalating doses of intermittent or continuous OSI-906 in patients with recurrent/relapsed ovarian and other solid tumors.

Interventions

  • DRUG Paclitaxel
  • DRUG OSI-906

Study Locations (20)

Western Australia

  • St. John of God Hospital, Bunbury — Bunbury
  • Sir Charles Gairdner Hospital — Perth
  • St. John of Gog Hospital, Subiaco — Subiaco

North Carolina

  • Blumenthal Cancer Center - Main — Charlotte
  • Duke University Medical Center — Durham

Victoria

  • Frankston Hospital — Frankston
  • Border Medical Oncology — Wodonga

Ontario

  • Juravinski Cancer Center — Hamilton
  • Princess Margaret Hospital — Toronto

Arizona

  • Mayo Clinic — Scottsdale

California

  • Department of Obstetrics and Gynecology, University of California, Irvine — Orange

Indiana

  • Horizon Oncology Center — Lafayette

Louisiana

  • Ochsner Clinic Foundation — New Orleans

Trial Details

FieldValue
Enrollment Target 152 participants
Start Date 2009-08-05
Est. Completion 2014-08-25
Phase Phase 1

Sponsor

Astellas Pharma

51 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00889382

The ClinicalTrials.gov registry entry for NCT00889382 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 152 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Astellas Pharma, which has 51 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Ovarian Cancer appearing as the primary indexed condition, and to 2 interventions — of which Paclitaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00889382 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Western Australia, North Carolina, Victoria. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00889382 about?

NCT00889382 is a clinical study titled "A Study Evaluating Intermittent and Continuous OSI-906 and Weekly Paclitaxel in Patients With Recurrent Epithelial Ovarian Cancer (and Other Solid Tumors)". This is a multi-center, randomized, open-label, phase 1/2 study of continuous weekly paclitaxel and escalating doses of intermittent or continuous OSI-906 in patients with recurrent/relapsed ovarian and other solid tumors.

What is the current status of trial NCT00889382?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 152 participants. The study started on 2009-08-05. Estimated completion is 2014-08-25.

What conditions does trial NCT00889382 study?

This clinical trial studies the following conditions: Ovarian Cancer, Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00889382?

The interventions under investigation include: Paclitaxel (DRUG), OSI-906 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00889382?

This trial is sponsored by Astellas Pharma, which has 51 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00889382 being conducted?

This trial has 20 study locations across Arizona, California, Indiana, Louisiana, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial