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NCT05519579 · ClinicalTrials.gov registry record · Phase 2
Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia
A Phase 2 study of Acute Lymphoblastic Leukemia, sponsored by Northside Hospital.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT05519579: Recruiting Phase 2 study of Acute Lymphoblastic Leukemia, sponsored by Northside Hospital.
NCT05519579 is a Phase 2 study of Acute Lymphoblastic Leukemia that is actively recruiting participants, run by Northside Hospital. The registered enrollment target is 20 participants, below the 382-participant average among 131 other Acute Lymphoblastic Leukemia trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05519579, a Phase 2 study of Acute Lymphoblastic Leukemia, is actively recruiting participants, sponsored by Northside Hospital.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
Changing the schedule of intrathecal chemotherapy to be given before and during blinatumomab will maintain the anti-leukemic effects of this drug while at the same time adding the benefit of limiting the neurotoxicity associated with cytokine release.
Primary Outcome
Record occurrence and severity of neurotoxicity based on CTCAE criteria
Conditions Studied
Interventions
- DRUG Blinatumomab
- DRUG Methotrexate
Study Locations (1)
Georgia
- Northside Hospital - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2023-06-30 |
| Est. Completion | 2025-12-01 |
| Phase | Phase 2 |
What NCT05519579 shows while recruiting
NCT05519579 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 382-participant average among 131 other Acute Lymphoblastic Leukemia trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Acute Lymphoblastic Leukemia appearing as the primary indexed condition, and to 2 interventions - of which Blinatumomab is the first listed.
NCT05519579 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT05519579 about?
NCT05519579 is a clinical study titled "Intrathecal Chemoprophylaxis to Prevent Neurotoxicity Associated With Blinatumomab Therapy for Acute Lymphoblastic Leukemia". Changing the schedule of intrathecal chemotherapy to be given before and during blinatumomab will maintain the anti-leukemic effects of this drug while at the same time adding the benefit of limiting the neurotoxicity associated with cytokine release.
What is the current status of trial NCT05519579?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2023-06-30. Estimated completion is 2025-12-01.
What conditions does trial NCT05519579 study?
This clinical trial studies the following conditions: Acute Lymphoblastic Leukemia.
What interventions are being tested in trial NCT05519579?
The interventions under investigation include: Blinatumomab (DRUG), Methotrexate (DRUG).
Who is sponsoring clinical trial NCT05519579?
This trial is sponsored by Northside Hospital, which has 26 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05519579 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Acute Lymphoblastic Leukemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05519579's enrollment target sits among peer trials
20 103rd of 131 higher than 24 of 131 other Acute Lymphoblastic Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Lymphoblastic Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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