Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00756821 · ClinicalTrials.gov registry record
A Pilot Study of Biomarkers for Spinal Muscular Atrophy
A clinical trial of Spinal Muscular Atrophy, sponsored by Carelon Research.
- Completed
- Registry status
- 130
- Enrollment target
- 18
- Study locations
NCT00756821: Completed study of Spinal Muscular Atrophy, sponsored by Carelon Research.
NCT00756821 is a study of Spinal Muscular Atrophy that has completed, run by Carelon Research. The registered enrollment target is 130 participants, above the 103-participant average among 22 other Spinal Muscular Atrophy trials with a reported enrollment target (26% higher). The trial reports 18 study locations across 16 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00756821, a study of Spinal Muscular Atrophy, has completed, sponsored by Carelon Research.
- COMPLETED
- Registry status
- 130 participants
- Enrollment target
- 18
- Study locations
Study Summary
The goal of this pilot study is to identify a marker or panel of markers in the blood or urine from a wide range of Spinal Muscular Atrophy (SMA) patients that segregates with measures of clinical severity. From this identification of candidate biomarkers, it is hoped that further investigations, both longitudinal natural history and clinical efficacy studies, will verify a biomarker with the sensitivity and specificity that will allow its eventual use as a validated pharmacodynamic marker or surrogate endpoint. In addition, this effort may elucidate biological pathways that may be potential therapeutic targets.
Conditions Studied
Study Locations (18)
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
- The Ohio State University - Columbus
Ontario
- Children's Hospital - London Health Sciences Center - London
- The Hospital for Sick Children - Toronto
Alabama
- University of Alabama at Birmingham - Birmingham
California
- Stanford University - Stanford
Colorado
- The Children's Hospital - Aurora
Iowa
- University of Iowa - Iowa City
Maryland
- Johns Hopkins Hospital - Baltimore
Massachusetts
- Children's Hospital Boston - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 130 participants |
| Start Date | 2008-10 |
| Est. Completion | 2009-03 |
What the finished NCT00756821 record still lists
NCT00756821 is an observational study that tracks outcomes without assigning an intervention. The registered 130 participants enrollment target is mid-sized for trials with a published cap, above the 103-participant average among 22 other Spinal Muscular Atrophy trials with a reported enrollment target (26% higher).
The record links to 1 condition, with Spinal Muscular Atrophy appearing as the primary indexed condition, and to 0 interventions.
NCT00756821 lists 18 locations in 16 states (Ohio, Ontario, Alabama).
Frequently Asked Questions
What is clinical trial NCT00756821 about?
NCT00756821 is a clinical study titled "A Pilot Study of Biomarkers for Spinal Muscular Atrophy". The goal of this pilot study is to identify a marker or panel of markers in the blood or urine from a wide range of Spinal Muscular Atrophy (SMA) patients that segregates with measures of clinical severity. From this identification of candidate biomarkers, it is hoped that further investigations, bo...
What is the current status of trial NCT00756821?
This trial is currently completed. The enrollment target is 130 participants. The study started on 2008-10. Estimated completion is 2009-03.
What conditions does trial NCT00756821 study?
This clinical trial studies the following conditions: Spinal Muscular Atrophy.
Who is sponsoring clinical trial NCT00756821?
This trial is sponsored by Carelon Research, which has 50 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00756821 being conducted?
This trial has 18 study locations across Alabama, California, Colorado, Iowa, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Muscular Atrophy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00756821's enrollment target sits among peer trials
130 8th of 22 higher than 15 of 22 other Spinal Muscular Atrophy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Muscular Atrophy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Characterizing Perceived Physical Fatigability in Nusinersen-treated SMA
RECRUITING
-
Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease
RECRUITING · NA
-
Safety and Efficacy of NMD670 in Ambulatory Adult Patients With Type 3 Spinal Muscular Atrophy
RECRUITING · Phase 2
-
Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy
RECRUITING · NA
-
A Study to Evaluate How Apitegromab Works in Subjects Who Are Less Than 2 Years Old and Have Spinal Muscular Atrophy
RECRUITING · Phase 2
-
Exploring the Physiologic, Pharmacodynamic, and Clinical Responses of Skeletal Muscle in Patients With Spinal Muscular Atrophy Treated With SMN-Directed Therapies
RECRUITING
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01492036 · 130 participants
Long-Term Follow-Up of Recipient of Gene Transfer Research
- NCT01631617 · 130 participants · Phase 2
Effects of Treatments on Atopic Dermatitis
- NCT02368041 · 130 participants
Utility of Thenar Near Infrared Spectroscopy (NIRS) in Pediatric Patients With Heart Failure
- NCT02604277 · 130 participants · NA
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia