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NCT00692406 · ClinicalTrials.gov registry record · NA
Neuroimaging Attentional Impairment During Abstinence
A NA study, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 80
- Enrollment target
NCT00692406 is a NA study that has completed, run by Duke University. The registered enrollment target is 80 participants.
The verdict
NCT00692406, a NA study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
Study Summary
The broad objective of this proposal is to identify functional neuroanatomical correlates of impairments in sustained attention during smoking abstinence. We will measure changes in performance and regional blood oxygenation levels using fMRI while smokers and non-smokers complete a task designed to assess sustained attention-or the continuous monitoring of stimuli. Our primary hypothesis is that smoking abstinence will result in impaired sustained attention accompanied by decreases in blood-oxygenation-level-dependent (BOLD) fMRI signal in regions associated with sustained attention including right fronto-parietal cortex, thalamus and reticular activation system. Abstinence may also result in performance-related increases in activation in brain regions associated with effortful processing including the anterior cingulate cortex. We also hypothesize that smokers during the satiated state will exhibit brain activity more similar to that of non-smokers. In addition to task related brain responses, we will also measure changes in absolute regional cerebral blood flow (rCBF) and hypothesize that abstinence will result in significant decreases in regions associated with arousal (e.g., reticular activation system); information processing (e.g., thalamus); and emotional regulation (e.g., anterior cingulate cortex, prefrontal cortex).
Interventions
- BEHAVIORAL Smoking Abstinence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2005-06 |
| Est. Completion | 2009-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00692406
The ClinicalTrials.gov registry entry for NCT00692406 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Smoking Abstinence is the first listed.
NCT00692406 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00692406 about?
NCT00692406 is a clinical study titled "Neuroimaging Attentional Impairment During Abstinence". The broad objective of this proposal is to identify functional neuroanatomical correlates of impairments in sustained attention during smoking abstinence. We will measure changes in performance and regional blood oxygenation levels using fMRI while smokers and non-smokers complete a task designed to...
What is the current status of trial NCT00692406?
This trial is currently completed. It is a NA study. The enrollment target is 80 participants. The study started on 2005-06. Estimated completion is 2009-01.
What interventions are being tested in trial NCT00692406?
The interventions under investigation include: Smoking Abstinence (BEHAVIORAL).
Who is sponsoring clinical trial NCT00692406?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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