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COMPLETED

Transthyretin Amyloidosis Outcome Survey (THAOS)

NCT00628745 · View on ClinicalTrials.gov ↗

Study Summary

THAOS is a global, multi-center, longitudinal observational survey open to all patients with transthyretin amyloidosis (ATTR), including ATTR-PN (polyneuropathy), ATTR-CM (cardiomyopathy) and wild-type ATTR-CM. It is open-ended with a minimum duration of 10 years. Patients will be followed as long as they are able to participate. The principal aims of this outcome survey are to better understand and characterize the natural history of the disease by studying a large and heterogenous patient population. Survey data may be used to develop new treatment guidelines and recommendations, and to inform and educate clinicians about the management of this disease.

Interventions

  • OTHER None. Observational Study.

Study Locations (20)

California

  • VA Greater Los Angeles Healthcare System — Los Angeles
  • University of California, Irvine — Orange
  • University of California - San Francisco, UCSF Department of Neurology — San Francisco
  • Office of Sponsored Research — San Francisco
  • Stanford University School of Medicine — Stanford

Illinois

  • Clinical Trials Unit — Chicago
  • Northwestern University — Chicago
  • University of Chicago Medical Center IRB — Chicago
  • University of Chicago Medical Center — Chicago
  • Advocate Christ Medical Centre — Oak Lawn

Florida

  • UHealth Deerfield Beach — Deerfield Beach
  • University of Miami Hospital & Clinics — Miami
  • UHealth Plantation — Plantation

Maryland

  • University of Maryland School of Medicine — Baltimore
  • University of Maryland — Baltimore

Alabama

  • University of Alabama at Birmingham — Birmingham

Arizona

  • Mayo Clinic Arizona — Phoenix

Colorado

  • UC Denver — Aurora

Connecticut

  • Smilow Cancer Hospital at Yale-New Haven — New Haven

Trial Details

FieldValue
Enrollment Target 6,718 participants
Start Date 2008-01-04
Est. Completion 2023-06-19

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00628745

The ClinicalTrials.gov registry entry for NCT00628745 describes a study currently listed as completed. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 6,718 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Transthyretin Amyloidosis appearing as the primary indexed condition, and to 1 intervention — of which None. Observational Study. is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00628745 reports 20 study locations spanning 9 distinct geographic areas — top geographies include California, Illinois, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00628745 about?

NCT00628745 is a clinical study titled "Transthyretin Amyloidosis Outcome Survey (THAOS)". THAOS is a global, multi-center, longitudinal observational survey open to all patients with transthyretin amyloidosis (ATTR), including ATTR-PN (polyneuropathy), ATTR-CM (cardiomyopathy) and wild-type ATTR-CM. It is open-ended with a minimum duration of 10 years. Patients will be followed as long a...

What is the current status of trial NCT00628745?

This trial is currently completed. The enrollment target is 6,718 participants. The study started on 2008-01-04. Estimated completion is 2023-06-19.

What conditions does trial NCT00628745 study?

This clinical trial studies the following conditions: Transthyretin Amyloidosis, Transthyretin Gene Mutations. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00628745?

The interventions under investigation include: None. Observational Study. (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00628745?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00628745 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial