Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00621816 · ClinicalTrials.gov registry record · Phase 2
Sodium Nitroprusside for Blood Pressure Reduction in the ICU (SNP2)
A Phase 2 study of Hypertension, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- Completed
- Registry status
- Phase 2
- Development phase
- 45
- Enrollment target
- 8
- Study locations
NCT00621816: Completed Phase 2 study of Hypertension, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
NCT00621816 is a Phase 2 study of Hypertension that has completed, run by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The registered enrollment target is 45 participants, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (99% lower). The trial reports 8 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00621816, a Phase 2 study of Hypertension, has completed, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 45 participants
- Enrollment target
- 8
- Study locations
Study Summary
Nitroprusside is used commonly in the Intensive Care Unit for long periods of time in order to reduce blood pressure. It is not known if the body compensates over time to the blood pressure lowering, and if when the nitroprusside is stopped the blood pressure goes up at a faster rate and is higher than it was at the start of the treatment. This study will answer these questions.
Conditions Studied
Interventions
- DRUG nitroprusside
- DRUG placebo infusion
Study Locations (8)
North Carolina
- University of North Carolina - Chapel Hill - Chapel Hill
- Duke University Medical Center - Durham
- Duke University Medical Center - Durham
Arkansas
- Arkansas Children's Hospital - Little Rock
California
- Stanford University School of Medicine - Stanford
Kentucky
- Kosair Charities Pediatric Clinical Research Unit - Louisville
Michigan
- University of Michigan - Mott Children's Hospital - Ann Arbor
West Virginia
- West Virginia University - Morgantown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2009-01 |
| Est. Completion | 2011-01 |
| Phase | Phase 2 |
Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)305 total trials
What the finished NCT00621816 record still lists
NCT00621816 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 3,507-participant average among 470 other Hypertension trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 2 interventions - of which nitroprusside is the first listed.
NCT00621816 lists 8 locations in 6 states (North Carolina, Arkansas, California).
Frequently Asked Questions
What is clinical trial NCT00621816 about?
NCT00621816 is a clinical study titled "Sodium Nitroprusside for Blood Pressure Reduction in the ICU (SNP2)". Nitroprusside is used commonly in the Intensive Care Unit for long periods of time in order to reduce blood pressure. It is not known if the body compensates over time to the blood pressure lowering, and if when the nitroprusside is stopped the blood pressure goes up at a faster rate and is higher t...
What is the current status of trial NCT00621816?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 45 participants. The study started on 2009-01. Estimated completion is 2011-01.
What conditions does trial NCT00621816 study?
This clinical trial studies the following conditions: Hypertension.
What interventions are being tested in trial NCT00621816?
The interventions under investigation include: nitroprusside (DRUG), placebo infusion (DRUG).
Who is sponsoring clinical trial NCT00621816?
This trial is sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which has 305 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00621816 being conducted?
This trial has 8 study locations across Arkansas, California, Kentucky, Michigan, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hypertension
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00621816's enrollment target sits among peer trials
45 380th of 470 higher than 91 of 470 other Hypertension trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hypertension trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults
RECRUITING · Phase 2
-
A Study to Identify an Optimal Dose of QCZ484 in Mild to Moderate Hypertensive Patients
RECRUITING · Phase 2
-
Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension
RECRUITING · Phase 2
-
Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)
RECRUITING · Phase 2
-
PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
RECRUITING · Phase 2
-
Virtual Diabetes Group Visits Across Health Systems
ACTIVE NOT RECRUITING · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT00804154 · 45 participants · Phase 1
Resiniferatoxin to Treat Severe Pain Associated With Advanced Cancer
- NCT01851694 · 45 participants · NA
Beta-cell Response to Incretin Hormones in Cystic Fibrosis
- NCT02896335 · 45 participants · Phase 2
Palbociclib and Pembrolizumab In Central Nervous System Metastases
- NCT03454035 · 45 participants · Phase 1
Ulixertinib/Palbociclib in Patients With Advanced Pancreatic and Other Solid Tumors
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia