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Sodium Nitroprusside for Blood Pressure Reduction in the ICU (SNP2)
NCT00621816 · View on ClinicalTrials.gov ↗
Study Summary
Nitroprusside is used commonly in the Intensive Care Unit for long periods of time in order to reduce blood pressure. It is not known if the body compensates over time to the blood pressure lowering, and if when the nitroprusside is stopped the blood pressure goes up at a faster rate and is higher than it was at the start of the treatment. This study will answer these questions.
Conditions Studied
Interventions
- DRUG nitroprusside
- DRUG placebo infusion
Study Locations (8)
North Carolina
- University of North Carolina - Chapel Hill — Chapel Hill
- Duke University Medical Center — Durham
- Duke University Medical Center — Durham
Arkansas
- Arkansas Children's Hospital — Little Rock
California
- Stanford University School of Medicine — Stanford
Kentucky
- Kosair Charities Pediatric Clinical Research Unit — Louisville
Michigan
- University of Michigan - Mott Children's Hospital — Ann Arbor
West Virginia
- West Virginia University — Morgantown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2009-01 |
| Est. Completion | 2011-01 |
| Phase | Phase 2 |
Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)237 total trials
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00621816
The ClinicalTrials.gov registry entry for NCT00621816 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which has 237 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Hypertension appearing as the primary indexed condition, and to 2 interventions — of which nitroprusside is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00621816 reports 8 study locations spanning 6 distinct geographic areas — top geographies include North Carolina, Arkansas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00621816 about?
NCT00621816 is a clinical study titled "Sodium Nitroprusside for Blood Pressure Reduction in the ICU (SNP2)". Nitroprusside is used commonly in the Intensive Care Unit for long periods of time in order to reduce blood pressure. It is not known if the body compensates over time to the blood pressure lowering, and if when the nitroprusside is stopped the blood pressure goes up at a faster rate and is higher t...
What is the current status of trial NCT00621816?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 45 participants. The study started on 2009-01. Estimated completion is 2011-01.
What conditions does trial NCT00621816 study?
This clinical trial studies the following conditions: Hypertension. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00621816?
The interventions under investigation include: nitroprusside (DRUG), placebo infusion (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00621816?
This trial is sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which has 237 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00621816 being conducted?
This trial has 8 study locations across Arkansas, California, Kentucky, Michigan, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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