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NCT00361257 · ClinicalTrials.gov registry record · Phase 2
Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults
A Phase 2 study, sponsored by Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections.
- Terminated
- Registry status
- Phase 2
- Development phase
- 107
- Enrollment target
NCT00361257: Clinical Trial Phase 2 study, sponsored by Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections.
NCT00361257 is a Phase 2 study that was terminated before completion, run by Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections. The registered enrollment target is 107 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (20% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00361257, a Phase 2 study, was terminated before completion, sponsored by Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 107 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the effectiveness of minocycline, an antibiotic, in lessening the decreased mental function sometimes caused by anti-HIV drugs.
Primary Outcome
Th cognitive performance is measured by NPZ-8. NPZ-8 is defined as the average of age and education adjusted z-scores of eight neuropsychological tests subcomponents in the neuropsychological test battery. These eight tests are: 1. Grooved Pegboard Dominant Hand (GPD) 2. Grooved Pegboard Non-dominant hand (GPN) 3. Choice Reaction Time (CRT) 4. Sequential Reaction Time (QRT) 5. Timed Gait (TIG) 6. Trail Making Part A (TMA) 7. Trail Making Part B (TMB) 8. Symbol Digit (SYD) The primary outcome is
Interventions
- DRUG Minocycline
- DRUG Placebo (Tetracycline)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 107 participants |
| Start Date | 2007-03 |
| Est. Completion | 2010-01 |
| Phase | Phase 2 |
Why NCT00361257 stopped before completion
NCT00361257 is an interventional study that assigns participants to a tested intervention. The registered 107 participants enrollment target is mid-sized for trials with a published cap, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (20% lower).
The record links to 0 conditions, and to 2 interventions - of which Minocycline is the first listed.
NCT00361257 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00361257 about?
NCT00361257 is a clinical study titled "Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults". The purpose of this study is to determine the effectiveness of minocycline, an antibiotic, in lessening the decreased mental function sometimes caused by anti-HIV drugs.
What is the current status of trial NCT00361257?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 107 participants. The study started on 2007-03. Estimated completion is 2010-01.
What interventions are being tested in trial NCT00361257?
The interventions under investigation include: Minocycline (DRUG), Placebo (Tetracycline) (DRUG).
Who is sponsoring clinical trial NCT00361257?
This trial is sponsored by Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, which has 45 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00361257's enrollment target sits among peer trials
107 646th of 2000 higher than 1,353 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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