Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00342537 · ClinicalTrials.gov registry record
Genetics of Familial Testicular Cancer
A clinical trial, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- 1,842
- Enrollment target
NCT00342537: Completed study, sponsored by National Cancer Institute (NCI).
NCT00342537 is a clinical trial that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 1,842 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00342537 has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- 1,842 participants
- Enrollment target
Study Summary
This study is a collaboration between the Clinical Genetics Branch of the National Cancer Institute and the International Testicular Cancer Linkage Consortium (ITCLC). The primary goal of the ITCLC is mapping and cloning susceptibility genes for familial TGCT. The objectives of the current study are to: * Identify the genes responsible for testicular germ cell tumor (TGCT) (testicular cancer) in families with an inherited tendency to develop the disease * Determine if the genes which predispose to developing testicular cancer also increase the risk of other specific types of cancer among first- and second-degree relatives of patients with TGCT * Determine if the microscopic appearance of familial testicular cancers is different from that of non-familial TGCT Patients and family members recruited by the ITCLC in the United Kingdom, the Netherlands, and Norway are eligible for this study. Individuals with the following medical criteria may participate: * Patients with testicular germ cell cancer who have at least one other blood relative with the disease * Family members of patients (first- and second-degree relatives) Participants undergo the following procedures: * Fill out questionnaires for providing information about a history of cancer in all blood relatives, including parents, siblings, children, grandparents, aunts, uncles, and cousins, and a history of undescended testes in male blood relatives. Participants may be asked permission to contact family members to request their help in the study as well. * Provide a blood sample for genetic testing related to TGCT (except in children under 16 years old). * Review of medical records and examination of tumor specimen (patients with TGCT only). * Confirmation of the diagnosis of other types of cancer in these same families (medical records, pathology repots) * Review of the testicular cancer tissue obtained at the time of surgery from members of multiple case families, and comparison of these findings with a se
Primary Outcome
This outcome is the responsibility of the total ITCLC consortium, and will draw upon the collection of DNA samples from multiplecase TGCT families assembled for the purpose of gene discovery. That activity isseparate from the two substudies being proposed in the current document.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,842 participants |
| Start Date | 2004-01-02 |
| Est. Completion | 2020-07-14 |
What the finished NCT00342537 record still lists
NCT00342537 is an observational study that tracks outcomes without assigning an intervention. Its 1,842 participants enrollment target places it among the larger protocols in the corpus.
The record links to 0 conditions, and to 0 interventions.
NCT00342537 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00342537 about?
NCT00342537 is a clinical study titled "Genetics of Familial Testicular Cancer". This study is a collaboration between the Clinical Genetics Branch of the National Cancer Institute and the International Testicular Cancer Linkage Consortium (ITCLC). The primary goal of the ITCLC is mapping and cloning susceptibility genes for familial TGCT. The objectives of the current study are...
What is the current status of trial NCT00342537?
This trial is currently completed. The enrollment target is 1,842 participants. The study started on 2004-01-02. Estimated completion is 2020-07-14.
Who is sponsoring clinical trial NCT00342537?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06740630 · 1,840 participants · Phase 3
A Study on the Immune Response and Safety of an Investigational Chickenpox Vaccine When Given to Healthy Children 12 to 15 Months of Age
- NCT07104240 · 1,836 participants · NA
A Vaccine Promotion Package (TweenVax) to Improve Adolescent HPV Vaccination, TweenVax Trial
- NCT06465810 · 1,850 participants
Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis
- NCT06580080 · 1,850 participants · NA
Evaluation of Are You Ready?
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI