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NCT00341770 · ClinicalTrials.gov registry record
Assessment of Sympathetic Nervous System Activity by Microneurography Recording Technique
A clinical trial of Nervous System, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
- Completed
- Registry status
- 600
- Enrollment target
- 1
- Study location
NCT00341770: Completed study of Nervous System, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
NCT00341770 is a study of Nervous System that has completed, run by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The registered enrollment target is 600 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00341770, a study of Nervous System, has completed, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
- COMPLETED
- Registry status
- 600 participants
- Enrollment target
- 1
- Study location
Study Summary
Obesity is the consequence of an imbalance between energy intake and energy expenditure. Recent studies have suggested that the sympathetic nervous system (SNS) may be an important determinant of the rate of energy expenditure in man. Indirect assessments of the sympathetic nervous activity in Pima Indians have recently shown impaired SNS-mediated energy expenditure in this obesity-prone population. We plan to perform direct microelectrode nerve recording of the sympathetic innervation of the lower leg to directly assess SNS activity and examine its potential role in the regulation of metabolic rate and the development of obesity. Measurements will be performed in the basal state, in response to glucose feeding (75 g OGTT) and in response to glucose/insulin infusion. These studies also will help to disassociate the effect of insulin and glucose on the stimulation of SNS activity. Energy expenditure measurements will be performed over 24 hours in the respiratory chamber and for 2 1/2 hours before and during the euglycemic clamp. Results also will be used to determine possible racial differences between Pimas and Caucasians, since the risk for obesity is markedly different in these populations. To exclude the possibility of a "normal" SNS activity but with peripheral resistance to the action of norepineprine, we will perform adrenergic stimulation by isoproterenol to measure peripheral adrenergic sensitivity.
Conditions Studied
Study Locations (1)
Arizona
- NIDDK, Phoenix - Phoenix
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 600 participants |
| Start Date | 1991-04-12 |
| Est. Completion | 2010-11-23 |
What the finished NCT00341770 record still lists
NCT00341770 is an observational study that tracks outcomes without assigning an intervention. The registered 600 participants enrollment target is mid-sized for trials with a published cap.
The record links to 1 condition, with Nervous System appearing as the primary indexed condition, and to 0 interventions.
NCT00341770 reports a single indexed study location in Arizona.
Frequently Asked Questions
What is clinical trial NCT00341770 about?
NCT00341770 is a clinical study titled "Assessment of Sympathetic Nervous System Activity by Microneurography Recording Technique". Obesity is the consequence of an imbalance between energy intake and energy expenditure. Recent studies have suggested that the sympathetic nervous system (SNS) may be an important determinant of the rate of energy expenditure in man. Indirect assessments of the sympathetic nervous activity in Pima ...
What is the current status of trial NCT00341770?
This trial is currently completed. The enrollment target is 600 participants. The study started on 1991-04-12. Estimated completion is 2010-11-23.
What conditions does trial NCT00341770 study?
This clinical trial studies the following conditions: Nervous System.
Who is sponsoring clinical trial NCT00341770?
This trial is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which has 490 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00341770 being conducted?
This trial has 1 study location across Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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