Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00341068 · ClinicalTrials.gov registry record
Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population
A clinical trial, sponsored by National Human Genome Research Institute (NHGRI).
- Terminated
- Registry status
- 7,451
- Enrollment target
NCT00341068: Clinical Trial study, sponsored by National Human Genome Research Institute (NHGRI).
NCT00341068 is a clinical trial that was terminated before completion, run by National Human Genome Research Institute (NHGRI). The registered enrollment target is 7,451 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00341068 was terminated before completion, sponsored by National Human Genome Research Institute (NHGRI).
- TERMINATED
- Registry status
- 7,451 participants
- Enrollment target
Study Summary
In a collaborative effort with the Health Research Board, the national organization for medical research in the Republic of Ireland, individuals with neural tube defects (NTDs) or facial cleft defects and their parents will be studied. With the exception of a few well-described syndromes most cases of NTDs and facial clefts are not inherited in a Mendelian fashion. Nearly all incident cases occur in families with no prior history of the defects. The observed recurrence risk in families with an NTD child is 10-12 fold higher than the general population suggesting that inherited factors modify this risk. Historically, the incidence of NTDs in Ireland was 5-8 fold higher than the USA. The aim of this study is to identify the gene(s) involved in these defects using standard genetic epidemiology approaches, transmission disequilibrium testing and gene mapping strategies. We will initially evaluate genes known to be involved in folate metabolism and pattern formation (development of the body). The major outcomes measured will be aggregate allele frequencies in case groups compared to controls. Biochemical parameters in red cells and plasma will also be measured. Comparisons will be made between the presence of genetics variants, biochemical parameters and clinical phenotype. Characterizing the genes associated with these defects should provide insight into the etiology and metabolic processes that may be involved, furthering prevention and intervention efforts.
Primary Outcome
Develop list of candidate genes for these disorders
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7,451 participants |
| Start Date | 2000-01-01 |
| Est. Completion | 2019-12-02 |
Why NCT00341068 stopped before completion
NCT00341068 is an observational study that tracks outcomes without assigning an intervention. Its 7,451 participants enrollment target places it among the larger protocols in the corpus.
The record links to 0 conditions, and to 0 interventions.
NCT00341068 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00341068 about?
NCT00341068 is a clinical study titled "Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population". In a collaborative effort with the Health Research Board, the national organization for medical research in the Republic of Ireland, individuals with neural tube defects (NTDs) or facial cleft defects and their parents will be studied. With the exception of a few well-described syndromes most cases ...
What is the current status of trial NCT00341068?
This trial is currently terminated. The enrollment target is 7,451 participants. The study started on 2000-01-01. Estimated completion is 2019-12-02.
Who is sponsoring clinical trial NCT00341068?
This trial is sponsored by National Human Genome Research Institute (NHGRI), which has 185 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02915198 · 7,410 participants · Phase 4
Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
- NCT00439049 · 7,500 participants
Substance Abuse Pre-Treatment Screening Study
- NCT04809740 · 7,500 participants · NA
Evaluating the Implementation and Impact of Navigator-delivered ePRO System
- NCT05199701 · 7,500 participants · NA
Prospective Case Collection Study for New Mammography Technologies
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI