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NCT00304148 · ClinicalTrials.gov registry record

SDCC - Prospective Cohort Study of Chronic Renal Insufficiency

A clinical trial of Renal Insufficiency, Chronic, sponsored by University of Pennsylvania.

Active
Registry status
5,499
Enrollment target
12
Study locations

NCT00304148: Active study of Renal Insufficiency, Chronic, sponsored by University of Pennsylvania.

NCT00304148 is a study of Renal Insufficiency, Chronic that is active but no longer recruiting, run by University of Pennsylvania. The registered enrollment target is 5,499 participants, above the 257-participant average among 14 other Renal Insufficiency, Chronic trials with a reported enrollment target (2040% higher). The trial reports 12 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00304148, a study of Renal Insufficiency, Chronic, is active but no longer recruiting, sponsored by University of Pennsylvania.

ACTIVE NOT RECRUITING
Registry status
5,499 participants
Enrollment target
12
Study locations

Study Summary

Chronic kidney disease (CKD) is a silent epidemic affecting more than 37 million Americans. The burden of morbidity and mortality associated with CKD derives from its frequent progression to end-stage kidney disease (ESKD) and the disproportionate risk of cardiovascular disease (CVD) and associated complications. CKD is strongly and independently associated with CVD, even after adjustment for traditional CVD risk factors. This led to the hypothesis that other risk factors augment the rate of CVD in the setting of CKD. Hence, many patients with progressive renal disease succumb to fatal CVD events before they need renal replacement therapy. The National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK) established the Chronic Renal Insufficiency Cohort (CRIC) Study in 2001 with the initial goal of elucidating the relationship between CKD and CVD. Since its inception, the CRIC Study has recruited and followed a racially and ethnically diverse cohort of over 5,000 participants with reduced kidney function from 13 clinical recruitment sites across the US. The original aim of CRIC was to establish a clinical research laboratory designed to (a) identify novel predictors of CKD progression, and (b) characterize the manifestations of CVD and identify its risk factors among individuals with CKD. The CRIC Study has examined a broad set of etiological factors (clinical, behavioral, and biomarker-associated) potentially responsible for both progressive CKD and CKD-related morbidities, especially those early in the course of CKD. Characterizing relationships between these risk factors and outcomes should facilitate identification of high-risk subgroups with CKD and guide enrollment into preventive treatment trials and application of preventive therapies. Over time, the scientific focus and the CRIC investigator network have broadened extensively through a highly successful ancillary studies program that has included more than 100 projects, most of which have been fu

Conditions Studied

Renal Insufficiency, Chronic

Study Locations (12)

Ohio

  • University Hospitals of Cleveland - Cleveland
  • Metrohealth Medical Center - Cleveland
  • Cleveland Clinic Foundation - Cleveland

California

  • Kaiser Permanente of Northern California - Oakland
  • University of California - San Francisco

Maryland

  • University of Maryland Medical System - Baltimore
  • Johns Hopkins Medical Institutions - Baltimore

Michigan

  • University of Michigan Hospitals - Ann Arbor
  • Wayne State - Harper University Hospital - Detroit

Illinois

  • University of Illinois at Chicago - Chicago

Louisiana

  • Tulane University Health Sciences Center - New Orleans

Pennsylvania

  • University of Pennsylvania Medical Center - Philadelphia

Trial Details

FieldValue
Enrollment Target 5,499 participants
Start Date 2003-07
Est. Completion 2028-06
University of Pennsylvania

1,423 total trials

What the registry record for NCT00304148 still lists

NCT00304148 is an observational study that tracks outcomes without assigning an intervention. Its 5,499 participants enrollment target places it among the larger protocols in the corpus, above the 257-participant average among 14 other Renal Insufficiency, Chronic trials with a reported enrollment target (2040% higher).

The record links to 1 condition, with Renal Insufficiency, Chronic appearing as the primary indexed condition, and to 0 interventions.

NCT00304148 lists 12 locations in 7 states (Ohio, California, Maryland).

Frequently Asked Questions

What is clinical trial NCT00304148 about?

NCT00304148 is a clinical study titled "SDCC - Prospective Cohort Study of Chronic Renal Insufficiency". Chronic kidney disease (CKD) is a silent epidemic affecting more than 37 million Americans. The burden of morbidity and mortality associated with CKD derives from its frequent progression to end-stage kidney disease (ESKD) and the disproportionate risk of cardiovascular disease (CVD) and associated ...

What is the current status of trial NCT00304148?

This trial is currently active not recruiting. The enrollment target is 5,499 participants. The study started on 2003-07. Estimated completion is 2028-06.

What conditions does trial NCT00304148 study?

This clinical trial studies the following conditions: Renal Insufficiency, Chronic.

Who is sponsoring clinical trial NCT00304148?

This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00304148 being conducted?

This trial has 12 study locations across California, Illinois, Louisiana, Maryland, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Renal Insufficiency, Chronic

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00304148's enrollment target sits among peer trials

5,499 1st of 14 higher than 14 of 14 other Renal Insufficiency, Chronic trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Renal Insufficiency, Chronic trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT00304148, the US trial registry maintained by the National Library of Medicine. NCT00304148 (large enrollment · multi site footprint · active not recruiting) retrieved and formatted by PlainTrial, see methodology.