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NCT02947750 · ClinicalTrials.gov registry record · Phase 2
Neurovascular Transduction During Exercise in Chronic Kidney Disease
A Phase 2 study of Renal Insufficiency, Chronic, sponsored by Emory University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 150
- Enrollment target
- 3
- Study locations
NCT02947750: Recruiting Phase 2 study of Renal Insufficiency, Chronic, sponsored by Emory University.
NCT02947750 is a Phase 2 study of Renal Insufficiency, Chronic that is actively recruiting participants, run by Emory University. The registered enrollment target is 150 participants, below the 639-participant average among 14 other Renal Insufficiency, Chronic trials with a reported enrollment target (77% lower). The trial reports 3 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02947750, a Phase 2 study of Renal Insufficiency, Chronic, is actively recruiting participants, sponsored by Emory University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 150 participants
- Enrollment target
- 3
- Study locations
Study Summary
The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and to explore what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate). This study will also test whether or not regular exercise on a bicycle and/or treatment with 6R-BH4 (Kuvan) pills, or histidine and beta-alanine supplementation improves these measures during exercise. 6R-BH4 is currently FDA-approved for use in patients with certain forms of a disease called phenylketonuria, but it is not currently FDA approved for blood pressure or exercise capacity in people with CKD.
Primary Outcome
Muscle oxygenation during exercise and sympathoexcitation will be measured.
Conditions Studied
Interventions
- OTHER Exercise training
- DRUG 6R-BH4
- OTHER 6R-BH4 placebo
- DIETARY_SUPPLEMENT Folic acid
- OTHER Stretching
Study Locations (3)
Georgia
- Emory University Hospital Midtown - Atlanta
- Emory University Hospital - Atlanta
- Atlanta VA Health Care System - Decatur
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2016-10 |
| Est. Completion | 2026-01 |
| Phase | Phase 2 |
What NCT02947750 shows while recruiting
NCT02947750 is an interventional study that assigns participants to a tested intervention. The registered 150 participants enrollment target is mid-sized for trials with a published cap, below the 639-participant average among 14 other Renal Insufficiency, Chronic trials with a reported enrollment target (77% lower).
The record links to 1 condition, with Renal Insufficiency, Chronic appearing as the primary indexed condition, and to 5 interventions - of which Exercise training is the first listed.
NCT02947750 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT02947750 about?
NCT02947750 is a clinical study titled "Neurovascular Transduction During Exercise in Chronic Kidney Disease". The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and to explore what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate). This study will also test ...
What is the current status of trial NCT02947750?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 150 participants. The study started on 2016-10. Estimated completion is 2026-01.
What conditions does trial NCT02947750 study?
This clinical trial studies the following conditions: Renal Insufficiency, Chronic.
What interventions are being tested in trial NCT02947750?
The interventions under investigation include: Exercise training (OTHER), 6R-BH4 (DRUG), 6R-BH4 placebo (OTHER), Folic acid (DIETARY_SUPPLEMENT), Stretching (OTHER).
Who is sponsoring clinical trial NCT02947750?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02947750 being conducted?
This trial has 3 study locations across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT02947750's enrollment target sits among peer trials
150 6th of 14 higher than 9 of 14 other Renal Insufficiency, Chronic trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Renal Insufficiency, Chronic trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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