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NCT00187538 · ClinicalTrials.gov registry record · NA
Effect of Dietary Protein Source on Calcium Metabolism
A NA study of Calcium Metabolism, sponsored by University of California, San Francisco.
- Completed
- Registry status
- NA
- Development phase
- 183
- Enrollment target
- 1
- Study location
NCT00187538: Completed NA study of Calcium Metabolism, sponsored by University of California, San Francisco.
NCT00187538 is a NA study of Calcium Metabolism that has completed, run by University of California, San Francisco. The registered enrollment target is 183 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00187538, a NA study of Calcium Metabolism, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- NA
- Development phase
- 183 participants
- Enrollment target
- 1
- Study location
Study Summary
Osteoporosis is a major health concern worldwide. While there are drugs available for the treatment and prevention of osteoporosis, they are not practical for population-wide prevention efforts. Demonstrating the effectiveness of safe and widely available dietary interventions to prevent osteoporosis could have important public health ramifications. Different food sources of dietary protein may have different effects on bone metabolism. Animal foods provide a dietary acid load that may lead to negative calcium balance and increased bone resorption. In contrast, vegetable sources of protein, while providing some acid due to their protein content, provide proportionally more base that counters the dietary acid load. The effect of dairy products, which are rich in animal protein but also contain potential base precursors not found in vegetable foods, has not been established. Finally, soy protein sources may have a dual benefit: soy foods provide base precursors as well as plant estrogens that may have a beneficial effect on bone. We are resubmitting this proposal to randomize postmenopausal women to one of four diets equal in calories, protein, calcium, and sodium. The diets will differ by having 80 percent of the protein from one of four sources: non-dairy animal, vegetable, dairy, or soy foods, resulting in significant differences among the diets in acid, base, and isoflavone content. All food will be prepared and provided by the General Clinical Research Center. The subjects will consume the diets for 6 weeks with measurements of acid-base status, isoflavone excretion, and calcium metabolism. This will be the first intervention study to examine the effect of different sources of dietary protein in whole foods on calcium metabolism. Eventually our findings could have substantial public health implications and provide a widely available and low risk means to help prevent osteoporosis.
Conditions Studied
Interventions
- BEHAVIORAL Dietary
Study Locations (1)
Maryland
- Johns Hopkins University - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 183 participants |
| Start Date | 2002-02 |
| Est. Completion | 2013-07 |
| Phase | NA |
What the finished NCT00187538 record still lists
NCT00187538 is an interventional study that assigns participants to a tested intervention. The registered 183 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Calcium Metabolism appearing as the primary indexed condition, and to 1 intervention - of which Dietary is the first listed.
NCT00187538 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00187538 about?
NCT00187538 is a clinical study titled "Effect of Dietary Protein Source on Calcium Metabolism". Osteoporosis is a major health concern worldwide. While there are drugs available for the treatment and prevention of osteoporosis, they are not practical for population-wide prevention efforts. Demonstrating the effectiveness of safe and widely available dietary interventions to prevent osteoporosi...
What is the current status of trial NCT00187538?
This trial is currently completed. It is a NA study. The enrollment target is 183 participants. The study started on 2002-02. Estimated completion is 2013-07.
What conditions does trial NCT00187538 study?
This clinical trial studies the following conditions: Calcium Metabolism.
What interventions are being tested in trial NCT00187538?
The interventions under investigation include: Dietary (BEHAVIORAL).
Who is sponsoring clinical trial NCT00187538?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00187538 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00187538's enrollment target sits among peer trials
183 584th of 2000 higher than 1,417 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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