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NCT00145639 · ClinicalTrials.gov registry record · Phase 2
Osteosarcoma1999-A Study Of Intensive Chemotherapy for Osteosarcoma
A Phase 2 study, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- Phase 2
- Development phase
- 80
- Enrollment target
NCT00145639: Completed Phase 2 study, sponsored by St. Jude Children's Research Hospital.
NCT00145639 is a Phase 2 study that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 80 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00145639, a Phase 2 study, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 80 participants
- Enrollment target
Study Summary
This trial (OS99) evaluates the use of ifosfamide, carboplatin, and doxorubicin in an up-front window before surgery for localized and resectable osteosarcoma. High-dose methotrexate, which may interfere with the dose-intensive delivery of other agents, is eliminated from the treatment of localized disease. The primary objective is to compare the response rate of pre-surgical chemotherapy comprised of ifosfamide, doxorubicin, and carboplatin to that obtained with ifosfamide and carboplatin in the St. Jude OS-91 trial for patients with non-metastatic resectable osteosarcoma. We hypothesize that the histologic response rate will be improved by the addition of one course of pre-operative chemotherapy on this trial compared to the previous OS-91 trial.
Interventions
- DRUG Ifosfamide, Carboplatin, Doxorubicin
- PROCEDURE Limb Sparing
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 1999-05 |
| Est. Completion | 2006-05 |
| Phase | Phase 2 |
What the finished NCT00145639 record still lists
NCT00145639 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 2 interventions - of which Ifosfamide, Carboplatin, Doxorubicin is the first listed.
NCT00145639 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00145639 about?
NCT00145639 is a clinical study titled "Osteosarcoma1999-A Study Of Intensive Chemotherapy for Osteosarcoma". This trial (OS99) evaluates the use of ifosfamide, carboplatin, and doxorubicin in an up-front window before surgery for localized and resectable osteosarcoma. High-dose methotrexate, which may interfere with the dose-intensive delivery of other agents, is eliminated from the treatment of localized ...
What is the current status of trial NCT00145639?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 80 participants. The study started on 1999-05. Estimated completion is 2006-05.
What interventions are being tested in trial NCT00145639?
The interventions under investigation include: Ifosfamide, Carboplatin, Doxorubicin (DRUG), Limb Sparing (PROCEDURE).
Who is sponsoring clinical trial NCT00145639?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00145639's enrollment target sits among peer trials
80 842nd of 2000 higher than 1,117 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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