Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer
NCT00103181 · View on ClinicalTrials.gov ↗
Study Summary
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy in different ways may kill any tumor cells that remain after surgery. It is not yet known whether whole breast radiation therapy is more effective than partial breast radiation therapy in treating breast cancer. PURPOSE: This randomized phase III trial is studying whole breast radiation therapy to see how well it works compared to partial breast radiation therapy in treating women who have undergone surgery for ductal carcinoma in situ or stage I or stage II breast cancer.
Conditions Studied
Interventions
- RADIATION brachytherapy
- RADIATION whole breast irradiation
- RADIATION 3-dimensional conformal accelerated partial breast irradiation
- RADIATION MammoSite or other single-entry intracavitary device
Study Locations (20)
California
- Auburn Radiation Oncology — Auburn
- Alta Bates Summit Comprehensive Cancer Center — Berkeley
- Peninsula Medical Center — Burlingame
- Radiation Oncology Centers - Cameron Park — Cameron Park
- Mercy Cancer Center at Mercy San Juan Medical Center — Carmichael
- Enloe Cancer Center at Enloe Medical Center — Chico
- Cancer Care Center at John Muir Health - Concord Campus — Concord
- City of Hope Comprehensive Cancer Center — Duarte
- North Bay Cancer Center — Fairfield
- California Cancer Center - Woodward Park Office — Fresno
- Kaiser Permanente Medical Center - Hayward — Hayward
- Rebecca and John Moores UCSD Cancer Center — La Jolla
- Jonsson Comprehensive Cancer Center at UCLA — Los Angeles
- Community Hospital of the Monterey Peninsula Comprehensive Cancer Center — Monterey
Arizona
- Arizona Center for Cancer Care - Peoria — Peoria
- Arizona Oncology Services Foundation — Phoenix
- Arizona Breast Cancer Specialists — Scottsdale
- Mayo Clinic Scottsdale — Scottsdale
Alabama
- UAB Comprehensive Cancer Center — Birmingham
Arkansas
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 4,216 participants |
| Start Date | 2005-03 |
| Est. Completion | 2018-08 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00103181
The ClinicalTrials.gov registry entry for NCT00103181 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 4,216 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is NSABP Foundation, which has 11 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Breast Cancer appearing as the primary indexed condition, and to 4 interventions — of which brachytherapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00103181 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Arizona, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00103181 about?
NCT00103181 is a clinical study titled "Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer". RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy in different ways may kill any tumor cells that remain after surgery. It is not yet known whether whole breast radiation therapy is more effective than partial breast radiation therapy in treating brea...
What is the current status of trial NCT00103181?
This trial is currently completed. It is a NA study. The enrollment target is 4,216 participants. The study started on 2005-03. Estimated completion is 2018-08.
What conditions does trial NCT00103181 study?
This clinical trial studies the following conditions: Breast Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00103181?
The interventions under investigation include: brachytherapy (RADIATION), whole breast irradiation (RADIATION), 3-dimensional conformal accelerated partial breast irradiation (RADIATION), MammoSite or other single-entry intracavitary device (RADIATION). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00103181?
This trial is sponsored by NSABP Foundation, which has 11 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00103181 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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