Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Preliminary Study of Safety and Efficacy of Nanocrystalline Silver Cream in Atopic Dermatitis (Eczema)
NCT00076375 · View on ClinicalTrials.gov ↗
Study Summary
Nanocrystalline silver (very small particles of silver) is the active ingredient in Acticoat dressings, which have been approved for the treatment of burns and other wounds. Silver has been used for decades as an effective antimicrobial agent. In animal studies, nanocrystalline silver cream (NPI) has also demonstrated anti-inflammatory activity. Thus, nanocrystalline silver cream is being evaluated in the treatment of inflammatory skin conditions such as atopic dermatitis (eczema). Approximately 180 study subjects with a definitive diagnosis of mild to moderate eczema will be enrolled in this study. Subjects will be randomly assigned to treatment with placebo, 0.5% NPI or 1% NPI for the 6-week treatment period. Assessments of treatment effect and safety will be performed weekly. Upon completion of the study, subjects may be eligible for 12 weeks of open-label treatment with 1% NPI.
Conditions Studied
Interventions
- DRUG Nanocrystalline silver cream (NPI)
Study Locations (19)
Alabama
- Radiant Research — Birmingham
- Medical Affliated Research Centers, Inc. — Huntsville
New York
- Sadick Dermatology & Aesthetic Surgery — New York
- Mount Sinai School of Medicine — New York
Ohio
- University Hospitals of Cleveland — Cleveland
- Radiant Research — Columbus
South Carolina
- National Allergy, Asthma & Urticaria Centers of Charleston, P.A. — Charleston
- Radiant Research — Greer
Colorado
- National Jewish Medical & Research Center — Denver
District of Columbia
- nTouch Research — Washington D.C.
Florida
- Radiant Research — West Palm Beach
Idaho
- Radiant Research — Boise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 180 participants |
| Start Date | 2003-11 |
| Est. Completion | 2004-04 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00076375
The ClinicalTrials.gov registry entry for NCT00076375 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 180 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nucryst Pharmaceuticals, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Atopic Dermatitis appearing as the primary indexed condition, and to 1 intervention — of which Nanocrystalline silver cream (NPI) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00076375 reports 19 study locations spanning 15 distinct geographic areas — top geographies include Alabama, New York, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00076375 about?
NCT00076375 is a clinical study titled "Preliminary Study of Safety and Efficacy of Nanocrystalline Silver Cream in Atopic Dermatitis (Eczema)". Nanocrystalline silver (very small particles of silver) is the active ingredient in Acticoat dressings, which have been approved for the treatment of burns and other wounds. Silver has been used for decades as an effective antimicrobial agent. In animal studies, nanocrystalline silver cream (NPI) ha...
What is the current status of trial NCT00076375?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 180 participants. The study started on 2003-11. Estimated completion is 2004-04.
What conditions does trial NCT00076375 study?
This clinical trial studies the following conditions: Atopic Dermatitis, Eczema. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00076375?
The interventions under investigation include: Nanocrystalline silver cream (NPI) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00076375?
This trial is sponsored by Nucryst Pharmaceuticals, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00076375 being conducted?
This trial has 19 study locations across Alabama, Colorado, District of Columbia, Florida, Idaho. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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