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Comparison of Radiation Therapy With or Without Combination Chemotherapy Following Surgery in Treating Patients With Stage I or Stage II Endometrial Cancer
NCT00006027 · View on ClinicalTrials.gov ↗
Study Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor tissue. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if radiation therapy is more effective with or without combination chemotherapy for endometrial cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without combination chemotherapy following surgery in treating patients who have stage I or stage II endometrial cancer.
Conditions Studied
Interventions
- DRUG cisplatin
- DRUG paclitaxel
- RADIATION radiation therapy
- PROCEDURE adjuvant therapy
Study Locations (20)
California
- Jonsson Comprehensive Cancer Center, UCLA — Los Angeles
- Community Hospital of Los Gatos — Los Gatos
- Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center — Orange
New York
- State University of New York Health Science Center at Brooklyn — Brooklyn
- Memorial Sloan-Kettering Cancer Center — New York
- Long Island Cancer Center at Stony Brook University Hospital — Stony Brook
North Carolina
- Lineberger Comprehensive Cancer Center, UNC — Chapel Hill
- Duke Comprehensive Cancer Center — Durham
- Comprehensive Cancer Center at Wake Forest University — Winston-Salem
Colorado
- University of Colorado Cancer Center at University of Colorado Health Sciences Center — Denver
Hawaii
- MBCCOP - Hawaii — Honolulu
Indiana
- Indiana University Cancer Center — Indianapolis
Iowa
- Holden Comprehensive Cancer Center at University of Iowa — Iowa City
Maryland
- Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support — Bethesda
Trial Details
| Field | Value |
|---|---|
| Start Date | 2000-08 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00006027
The ClinicalTrials.gov registry entry for NCT00006027 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. An enrollment target was not published in the registry record, which is common for early-stage or observational entries. The listed sponsor is Radiation Therapy Oncology Group, which has 37 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Endometrial Cancer appearing as the primary indexed condition, and to 4 interventions — of which cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00006027 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, New York, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00006027 about?
NCT00006027 is a clinical study titled "Comparison of Radiation Therapy With or Without Combination Chemotherapy Following Surgery in Treating Patients With Stage I or Stage II Endometrial Cancer". RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor tissue. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known if radiation therapy is more effective with or without combination chemotherapy for endometria...
What is the current status of trial NCT00006027?
This trial is currently completed. It is a Phase 3 study. The study started on 2000-08.
What conditions does trial NCT00006027 study?
This clinical trial studies the following conditions: Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00006027?
The interventions under investigation include: cisplatin (DRUG), paclitaxel (DRUG), radiation therapy (RADIATION), adjuvant therapy (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00006027?
This trial is sponsored by Radiation Therapy Oncology Group, which has 37 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00006027 being conducted?
This trial has 20 study locations across California, Colorado, Hawaii, Indiana, Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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