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COMPLETED Phase 3

Combination Chemotherapy in Treating Patients With Advanced Head and Neck Cancer

NCT00002888 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known whether cisplatin plus fluorouracil are more effective than paclitaxel plus cisplatin in treating patients with advanced head and neck cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of two combination chemotherapy regimens in treating patients with advanced head and neck cancer.

Conditions Studied

Interventions

  • DRUG cisplatin
  • DRUG paclitaxel
  • DRUG fluorouracil

Study Locations (20)

California

  • Beckman Research Institute, City of Hope — Duarte
  • Veterans Affairs Medical Center - Long Beach — Long Beach
  • USC/Norris Comprehensive Cancer Center — Los Angeles
  • Jonsson Comprehensive Cancer Center, UCLA — Los Angeles
  • Veterans Affairs Outpatient Clinic - Martinez — Martinez
  • CCOP - Bay Area Tumor Institute — Oakland
  • Chao Family Comprehensive Cancer Center — Orange
  • University of California Davis Medical Center — Sacramento
  • UCSF Cancer Center and Cancer Research Institute — San Francisco
  • CCOP - Santa Rosa Memorial Hospital — Santa Rosa
  • David Grant Medical Center — Travis Air Force Base

Arizona

  • CCOP - Greater Phoenix — Phoenix
  • Veterans Affairs Medical Center - Phoenix (Hayden) — Phoenix
  • Veterans Affairs Medical Center - Tucson — Tucson
  • Arizona Cancer Center — Tucson

Arkansas

  • University of Arkansas for Medical Sciences — Little Rock
  • Veterans Affairs Medical Center - Little Rock (McClellan) — Little Rock

Colorado

  • Veterans Affairs Medical Center - Denver — Denver
  • University of Colorado Cancer Center — Denver

Alabama

  • MBCCOP - University of South Alabama — Mobile

Trial Details

FieldValue
Start Date 1997-03
Est. Completion 2004-08
Phase Phase 3

Sponsor

Eastern Cooperative Oncology Group

30 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00002888

The ClinicalTrials.gov registry entry for NCT00002888 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. An enrollment target was not published in the registry record, which is common for early-stage or observational entries. The listed sponsor is Eastern Cooperative Oncology Group, which has 30 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Head and Neck Cancer appearing as the primary indexed condition, and to 3 interventions — of which cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00002888 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Arizona, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00002888 about?

NCT00002888 is a clinical study titled "Combination Chemotherapy in Treating Patients With Advanced Head and Neck Cancer". RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known whether cisplatin plus fluorouracil are more effective than paclitaxel plus cisplatin in treating patien...

What is the current status of trial NCT00002888?

This trial is currently completed. It is a Phase 3 study. The study started on 1997-03. Estimated completion is 2004-08.

What conditions does trial NCT00002888 study?

This clinical trial studies the following conditions: Head and Neck Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00002888?

The interventions under investigation include: cisplatin (DRUG), paclitaxel (DRUG), fluorouracil (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00002888?

This trial is sponsored by Eastern Cooperative Oncology Group, which has 30 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00002888 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial