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ClinicalTrials.gov official registry

Stage IV Melanoma clinical trials

All 15 indexed Stage IV Melanoma trials have closed enrollment.

15 US clinical trials ·

Stage IV Melanoma is the subject of 15 registered US clinical trials on ClinicalTrials.gov, none currently recruiting. 0 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 8 of these trials.

The research picture

Stage IV Melanoma has 15 registered US clinical trials; none are currently listed as recruiting, so most are completed or in follow-up.

0
recruiting participants now
0%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
8
top sponsor: National Cancer Institute (NCI)
Phase 18Phase 27

Active & Recent Trials

15 total, page 1 of 1

ACTIVE NOT RECRUITING Phase 2 30 participants

A Phase II Trial of PD-L1 Therapy Combined With Anti-VEGF Therapy in Unresectable or Metastatic Melanoma

Elizabeth Buchbinder, MD

NCT04356729

ACTIVE NOT RECRUITING Phase 1 2 participants

Neoadj Admin Autologous Tumor Infiltrating Lymphocytes & Pembrolizumab for Treatment of Adv Melanoma Patients

Richard Wu

NCT05176470

COMPLETED Phase 1 97 participants

E7080 (Lenvatinib) in Combination With Dacarbazine Versus Dacarbazine Alone as First Line Therapy in Patients With Stage IV Melanoma

Eisai

NCT01133977

COMPLETED Phase 2 75 participants

Study of Denileukin Diftitox in Participants With Stage IIIC and Stage IV Melanoma

Eisai

NCT01127451

COMPLETED Phase 2 74 participants

Sorafenib in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed By Surgery

National Cancer Institute (NCI)

NCT00119249

COMPLETED Phase 1 69 participants

Sorafenib and Temsirolimus in Treating Patients With Metastatic, Recurrent, or Unresectable Melanoma

National Cancer Institute (NCI)

NCT00349206

COMPLETED Phase 2 50 participants

Temozolomide and Thalidomide in Treating Patients With Brain Metastases Secondary to Melanoma

National Cancer Institute (NCI)

NCT00072163

COMPLETED Phase 2 50 participants

Vaccine Plus Interleukin-2 in Treating Patients With Advanced Melanoma

National Cancer Institute (NCI)

NCT00005949

COMPLETED Phase 1 40 participants

Imatinib Mesylate and Bevacizumab in Treating Patients With Advanced Melanoma or Other Advanced Cancers

National Cancer Institute (NCI)

NCT00074308

COMPLETED Phase 1 25 participants

Tremelimumab and CP-870,893 in Patients With Metastatic Melanoma

Abramson Cancer Center at Penn Medicine

NCT01103635

COMPLETED Phase 2 25 participants

Individualized Temozolomide in Treating Patients With Stage IV Melanoma That Cannot Be Removed By Surgery

Mayo Clinic

NCT01328535

COMPLETED Phase 1 24 participants

Decitabine in Treating Patients With Advanced Solid Tumors

National Cancer Institute (NCI)

NCT00030615

COMPLETED Phase 1 24 participants

Temsirolimus and Bryostatin 1 in Treating Patients With Unresectable or Metastatic Solid Tumors

National Cancer Institute (NCI)

NCT00112476

COMPLETED Phase 1 22 participants

Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers

Case Comprehensive Cancer Center

NCT00498979

COMPLETED Phase 2

flt3L With or Without Vaccine Therapy in Treating Patients With Metastatic Melanoma or Renal Cell Cancer

National Cancer Institute (NCI)

NCT00019396

Phase Distribution

PhaseTrial count
Phase 1 8
Phase 2 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Stage IV Melanoma Trial Landscape

15 indexed Stage IV Melanoma studies · 0 recruiting (0%).

Phase mix: 0 late (III/IV) vs 15 early (I/II).

Top sponsor: National Cancer Institute (NCI) (8 trials), 6 others listed. 15 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Stage IV Melanoma?

PlainTrial tracks 15 US clinical trials for Stage IV Melanoma, of which 0 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Stage IV Melanoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.